An avian model for the reversal of 6-hydroxydopamine induced rotating behaviour by neural grafting

Joseph Yanai; William F. Silverman; David Shamir

doi:10.1016/0304-3940(95)11361-Y

An avian model for the reversal of 6-hydroxydopamine induced rotating behaviour by neural grafting

Joseph Yanai, William F. Silverman, David Shamir

Department of Physiology and Cell Biology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A new animal model of parkinsonism was established in 'Black Silkie' chickens by means of unilateral injections of 6-hydroxydopamine into the substantia nigra. Apomorphine produced a strong contralateral turning pattern in the lesioned chickens, amphetamine had no effect. 6-OHDA treated animals received embryonic transplants of substantia nigra cell suspensions which caused them to cease rotating (P < 0.01). This finding allows us to add an avian model, which offers unique methodological advantages, for reversal of 6-OHDA-induced rotating behavior by transplantation.

Original language	English
Pages (from-to)	153-156
Number of pages	4
Journal	Neuroscience Letters
Volume	187
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(95)11361-Y
State	Published - 10 Mar 1995

Keywords

6-Hydroxydopamine
Amphetamine
Apomorphine
Domestic fowl
Neural grafting
Rotating behavior

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(95)11361-Y

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title = "An avian model for the reversal of 6-hydroxydopamine induced rotating behaviour by neural grafting",

abstract = "A new animal model of parkinsonism was established in 'Black Silkie' chickens by means of unilateral injections of 6-hydroxydopamine into the substantia nigra. Apomorphine produced a strong contralateral turning pattern in the lesioned chickens, amphetamine had no effect. 6-OHDA treated animals received embryonic transplants of substantia nigra cell suspensions which caused them to cease rotating (P < 0.01). This finding allows us to add an avian model, which offers unique methodological advantages, for reversal of 6-OHDA-induced rotating behavior by transplantation.",

keywords = "6-Hydroxydopamine, Amphetamine, Apomorphine, Domestic fowl, Neural grafting, Rotating behavior",

author = "Joseph Yanai and Silverman, {William F.} and David Shamir",

note = "Funding Information: Supportedin part by USPHS grant DA-6670 (JY) and the Israel Academyo f Sciencea ndH umanitie(sG rantno. 285/90)( WFS).",

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AB - A new animal model of parkinsonism was established in 'Black Silkie' chickens by means of unilateral injections of 6-hydroxydopamine into the substantia nigra. Apomorphine produced a strong contralateral turning pattern in the lesioned chickens, amphetamine had no effect. 6-OHDA treated animals received embryonic transplants of substantia nigra cell suspensions which caused them to cease rotating (P < 0.01). This finding allows us to add an avian model, which offers unique methodological advantages, for reversal of 6-OHDA-induced rotating behavior by transplantation.

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An avian model for the reversal of 6-hydroxydopamine induced rotating behaviour by neural grafting

Abstract

Keywords

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