Abstract
Purpose: The aim of this study is to assess the effects of maternal nifedipine administration on placental and fetal blood flow. Methods: A total of 29 patients with preterm labor diagnosis admitted to the tertiary care center, Zeynep Kamil Hospital, were evaluated. Before and 24–48 h after administration of oral nifedipine, Doppler ultrasound scan was carried out to measure fetal middle cerebral artery, ductus venosus, umbilical artery, and maternal uterine artery blood flow. Results: After 24 and 48 h of therapy, there were no changes in mean PI and RI in the umbilical arteries and ductus venosus (p > 0.05). Fetal middle cerebral artery and maternal uterine artery PI and RI values showed a significant reduction 24–48 h after oral nifedipine therapy (p < 0.05). Conclusions: Our study showed that 24 and 48 h after oral nifedipine therapy, there is a significant increase in fetal MCA and maternal uterine artery blood flow, while fetal umbilical artery and ductus venosus Doppler values do not change.
| Original language | English |
|---|---|
| Pages (from-to) | 685-688 |
| Number of pages | 4 |
| Journal | Archives of Gynecology and Obstetrics |
| Volume | 298 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1 Oct 2018 |
Keywords
- Ductus venosus
- Middle cerebral artery
- Nifedipine
- Umbilical artery
- Uterine artery
ASJC Scopus subject areas
- Obstetrics and Gynecology
