An image analysis toolbox for high-throughput C. elegans assays

Carolina Wählby, Lee Kamentsky, Zihan H. Liu, Tammy Riklin-Raviv, Annie L. Conery, Eyleen J. O'Rourke, Katherine L. Sokolnicki, Orane Visvikis, Vebjorn Ljosa, Javier E. Irazoqui, Polina Golland, Gary Ruvkun, Frederick M. Ausubel, Anne E. Carpenter

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

We present a toolbox for high-throughput screening of image-based Caenorhabditis elegans phenotypes. The image analysis algorithms measure morphological phenotypes in individual worms and are effective for a variety of assays and imaging systems. This WormToolbox is available through the open-source CellProfiler project and enables objective scoring of whole-worm high-throughput image-based assays of C. elegans for the study of diverse biological pathways that are relevant to human disease.

Original languageEnglish
Pages (from-to)714-716
Number of pages3
JournalNature Methods
Volume9
Issue number7
DOIs
StatePublished - 1 Jul 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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