An improved method for Organic Bound Tritium (OBT) determination in urine samples

R. Gonen, R. Marco, U. German, E. Katorza, Z. B. Alfassi, G. Haquin, A. Tshuva, O. Pelled

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The Organic Bound Tritium (OBT) amount in the body may induce changes in the evaluation of the internal exposure to tritium, due to its different retention time relative to HTO. OBT measurements for urine are not performed routinely, mainly because of the lengthy work needed in preparation of the samples, when using the standard oxygen combustion method. A simpler and more rapid method based on liquid scintillation counting (LSC) was employed, and an evaluation was performed to check its suitability for urine samples. The principle of the proposed method is based on subtracting the LSC counts of the water phase sample (HTO) from the total activity of the urine sample (OBT + HTO). A good correlation was found between the results obtained when applying the proposed direct method and the Gold standard method. The minimum detectable activity when using this method was determined.

Original languageEnglish
Pages (from-to)460-464
Number of pages5
JournalRadiation Protection Dosimetry
Issue number1-4
StatePublished - 1 Dec 2007

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Radiation
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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