An Investigation of the Effects of Ultrasound on Degradable Polyanhydride Matrices

Antony D'Emanuele; Joseph Kost; Jennifer L. Hill; Robert Langer; Antony D'Emanuele

doi:10.1021/ma00028a002

An Investigation of the Effects of Ultrasound on Degradable Polyanhydride Matrices

Antony D'Emanuele, Joseph Kost, Jennifer L. Hill, Robert Langer, Antony D'Emanuele

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

In vitro methodology has been developed to investigate the effects of therapeutic ultrasound on polymer erosion. Enhancement in the rate of polymer erosion was demonstrated using therapeutically acceptable levels of ultrasound on a model class of degradable polymers—polyanhydrides. It was found that ultrasound enhances polymer degradation as demonstrated by the enhanced decrease in polymer molecular weight during the induction period of erosion. Additionally, morphological changes on the surface of ultrasound exposed devices were assessed by environmental scanning electron microscopy and suggested that cavitation may cause the mechanical disintegration of the polymer surface.

Original language	English
Pages (from-to)	511-515
Number of pages	5
Journal	Macromolecules
Volume	25
Issue number	2
DOIs	https://doi.org/10.1021/ma00028a002
State	Published - 1 Mar 1992

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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abstract = "In vitro methodology has been developed to investigate the effects of therapeutic ultrasound on polymer erosion. Enhancement in the rate of polymer erosion was demonstrated using therapeutically acceptable levels of ultrasound on a model class of degradable polymers—polyanhydrides. It was found that ultrasound enhances polymer degradation as demonstrated by the enhanced decrease in polymer molecular weight during the induction period of erosion. Additionally, morphological changes on the surface of ultrasound exposed devices were assessed by environmental scanning electron microscopy and suggested that cavitation may cause the mechanical disintegration of the polymer surface.",

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N2 - In vitro methodology has been developed to investigate the effects of therapeutic ultrasound on polymer erosion. Enhancement in the rate of polymer erosion was demonstrated using therapeutically acceptable levels of ultrasound on a model class of degradable polymers—polyanhydrides. It was found that ultrasound enhances polymer degradation as demonstrated by the enhanced decrease in polymer molecular weight during the induction period of erosion. Additionally, morphological changes on the surface of ultrasound exposed devices were assessed by environmental scanning electron microscopy and suggested that cavitation may cause the mechanical disintegration of the polymer surface.

AB - In vitro methodology has been developed to investigate the effects of therapeutic ultrasound on polymer erosion. Enhancement in the rate of polymer erosion was demonstrated using therapeutically acceptable levels of ultrasound on a model class of degradable polymers—polyanhydrides. It was found that ultrasound enhances polymer degradation as demonstrated by the enhanced decrease in polymer molecular weight during the induction period of erosion. Additionally, morphological changes on the surface of ultrasound exposed devices were assessed by environmental scanning electron microscopy and suggested that cavitation may cause the mechanical disintegration of the polymer surface.

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An Investigation of the Effects of Ultrasound on Degradable Polyanhydride Matrices

Abstract

ASJC Scopus subject areas

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