An Investigation of the Effects of Ultrasound on Degradable Polyanhydride Matrices

Antony D'Emanuele, Joseph Kost, Jennifer L. Hill, Robert Langer, Antony D'Emanuele, Joseph Kost

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

In vitro methodology has been developed to investigate the effects of therapeutic ultrasound on polymer erosion. Enhancement in the rate of polymer erosion was demonstrated using therapeutically acceptable levels of ultrasound on a model class of degradable polymers—polyanhydrides. It was found that ultrasound enhances polymer degradation as demonstrated by the enhanced decrease in polymer molecular weight during the induction period of erosion. Additionally, morphological changes on the surface of ultrasound exposed devices were assessed by environmental scanning electron microscopy and suggested that cavitation may cause the mechanical disintegration of the polymer surface.

Original languageEnglish
Pages (from-to)511-515
Number of pages5
JournalMacromolecules
Volume25
Issue number2
DOIs
StatePublished - 1 Mar 1992
Externally publishedYes

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