An update on molecular genetic studies of human personality traits.

Richard P. Ebstein, Ada H. Zohar, Jonathan Benjamin, Robert H. Belmaker

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Personality is a complex phenotype and people differ considerably when they are evaluated by self-report questionnaires. There is convincing evidence from twin studies that basic personality dimensions in men and women have a considerable genetic component. However, only recently have common genetic polymorphisms been associated with particular personality traits, especially the dopamine D4 receptor with novelty seeking and the serotonin transporter with anxiety-related traits or neuroticism. The current review examines progress in the past few years in molecular personality genetics and focuses on the reasons for difficulties in replicating first findings as well as the prospects for future studies in this area. The molecular genetic structure of human personality is worth studying both for its intrinsic interest in helping us to understand individual differences in human behaviour and the light it will shed on more complex behavioural disorders that are likely to partially share some common genetic variants.

Original languageEnglish
Pages (from-to)57-68
Number of pages12
JournalApplied Bioinformatics
Issue number2
StatePublished - 1 Jan 2002
Externally publishedYes

ASJC Scopus subject areas

  • Information Systems
  • Agricultural and Biological Sciences (all)
  • Computer Science Applications


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