An update on smallpox vaccine candidates and their role in bioterrorism related vaccination strategies

Itay Wiser, Ran D. Balicer, Dani Cohen

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

The threat of using variola virus in a bioterrorist attack urged different countries to renew the production of traditional vaccines and develop new generations of smallpox vaccines. Manufacturers try to combine smallpox vaccine past experience with technological advances in vaccine development to achieve protection similar to that of the traditional vaccines with a higher level of safety and fewer contraindications. In light of the reported immunogenicity and reactogenicity of the stockpiled smallpox vaccines employed in the last immunization campaigns of "first responders", we review recently accumulated data on the assessment of new smallpox vaccine candidates and discuss their role in possible vaccination policies.

Original languageEnglish
Pages (from-to)976-984
Number of pages9
JournalVaccine
Volume25
Issue number6
DOIs
StatePublished - 22 Jan 2007

Keywords

  • Bioterrorism
  • Smallpox vaccination policy
  • Smallpox vaccine
  • Variola

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology (all)
  • Veterinary (all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'An update on smallpox vaccine candidates and their role in bioterrorism related vaccination strategies'. Together they form a unique fingerprint.

Cite this