Analysis of interferograms of multi-layered biological samples obtained from full field optical coherence tomography systems

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4 Scopus citations

Abstract

Several methods were developed in the past to analyze interferograms produced by optical coherence tomography, and successfully applied to simulated or animated samples. However, these techniques do not cope with noisy and distorted interferograms from biological tissues. In this paper, known techniques, including the fast Fourier transform and several variations of the continuous wavelet transform, were employed to analyze the interferogram data. However, to cope with the difficulties in biological data, pre- and post-processing procedures and adaptive thresholding were developed to provide stability and robustness. Additionally, three-dimensional structural models of the biological samples were constructed, and revealed information like the number and locations of interfaces, the layer thickness and pattern, and abnormalities.

Original languageEnglish
Pages (from-to)8390-8400
Number of pages11
JournalApplied Optics
Volume51
Issue number35
DOIs
StatePublished - 10 Dec 2012

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

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