Abstract
The potential value of interleukin 1 (IL-1) containing supernatants as a radioprotective agent was evaluated. It was found that the response of irradiated thymocytes to mitogens was partially restored if IL-1 containing supernatants was included in the culture medium immediately after irradiation. A delay of 24 h in the addition of IL-1 and mitogen abrogated the radioprotection effect. Under the same conditions IL-2 containing supernatants were effective, suggesting that the dose modifiying effect of IL-1 acts through induction of IL-2 elaboration. The results of the present study may be important in cases where it is necessary to restore depressed immune response resulting from irradiation accidents or radiotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 526-532 |
| Number of pages | 7 |
| Journal | Clinical and Experimental Immunology |
| Volume | 63 |
| Issue number | 3 |
| State | Published - 1 Jan 1986 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology