Analysis of Lymphoid Cell Types Developing in Mouse Foetal Liver

T. Umiel; A. Globerson

doi:10.1111/j.1432-0436.1974.tb00350.x

Analysis of Lymphoid Cell Types Developing in Mouse Foetal Liver

T. Umiel, A. Globerson

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The aim of the present study was to determine which lymphoid cell types, the T or the B cell population, develop in the liver during ontogeny. We employed thymus-dependent antigens, i.e. SRBC, as well as thymus-independent antigens, DNP-PLL and PVP, in both in vitro and in vivo systems. It was demonstrated that the embryonic liver contains precursors of B cells, but not T helper cells. However, the B precursor cells in the liver require a phase of differentiation and/or proliferation in the spleen to produce a detectable antibody response. In contrast, T helper cells could not be detected in the liver in this study.

Original language	English
Pages (from-to)	169-178
Number of pages	10
Journal	Differentiation
Volume	2
Issue number	3
DOIs	https://doi.org/10.1111/j.1432-0436.1974.tb00350.x
State	Published - 1 Jan 1974
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology
Cancer Research

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10.1111/j.1432-0436.1974.tb00350.x

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abstract = "The aim of the present study was to determine which lymphoid cell types, the T or the B cell population, develop in the liver during ontogeny. We employed thymus-dependent antigens, i.e. SRBC, as well as thymus-independent antigens, DNP-PLL and PVP, in both in vitro and in vivo systems. It was demonstrated that the embryonic liver contains precursors of B cells, but not T helper cells. However, the B precursor cells in the liver require a phase of differentiation and/or proliferation in the spleen to produce a detectable antibody response. In contrast, T helper cells could not be detected in the liver in this study.",

author = "T. Umiel and A. Globerson",

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AU - Globerson, A.

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AB - The aim of the present study was to determine which lymphoid cell types, the T or the B cell population, develop in the liver during ontogeny. We employed thymus-dependent antigens, i.e. SRBC, as well as thymus-independent antigens, DNP-PLL and PVP, in both in vitro and in vivo systems. It was demonstrated that the embryonic liver contains precursors of B cells, but not T helper cells. However, the B precursor cells in the liver require a phase of differentiation and/or proliferation in the spleen to produce a detectable antibody response. In contrast, T helper cells could not be detected in the liver in this study.

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Analysis of Lymphoid Cell Types Developing in Mouse Foetal Liver

Abstract

ASJC Scopus subject areas

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