Analysis of Lymphoid Cell Types Developing in Mouse Foetal Liver

T. Umiel, A. Globerson

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The aim of the present study was to determine which lymphoid cell types, the T or the B cell population, develop in the liver during ontogeny. We employed thymus-dependent antigens, i.e. SRBC, as well as thymus-independent antigens, DNP-PLL and PVP, in both in vitro and in vivo systems. It was demonstrated that the embryonic liver contains precursors of B cells, but not T helper cells. However, the B precursor cells in the liver require a phase of differentiation and/or proliferation in the spleen to produce a detectable antibody response. In contrast, T helper cells could not be detected in the liver in this study.

Original languageEnglish
Pages (from-to)169-178
Number of pages10
Issue number3
StatePublished - 1 Jan 1974
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology
  • Cancer Research


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