Analytical and numerical analyses of the micromechanics of soft fibrous connective tissues

Gal Debotton, Tal Oren

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

State of the art research and treatment of biological tissues require accurate and efficient methods for describing their mechanical properties. Indeed, micromechanics-motivated approaches provide a systematic method for elevating relevant data from the microscopic level to the macroscopic one. In this work, the mechanical responses of hyperelastic tissues with one and two families of collagen fibers are analyzed by application of a new variational estimate accounting for their histology and the behaviors of their constituents. The resulting close-form expressions are used to determine the overall response of the wall of a healthy human coronary artery. To demonstrate the accuracy of the proposed method, these predictions are compared with corresponding 3D finite element simulations of a periodic unit cell of the tissue with two families of fibers. Throughout, the analytical predictions for the highly nonlinear and anisotropic tissue are in agreement with the numerical simulations.

Original languageEnglish
Pages (from-to)151-166
Number of pages16
JournalBiomechanics and Modeling in Mechanobiology
Volume12
Issue number1
DOIs
StatePublished - 1 Jan 2013

Keywords

  • Anisotropy
  • Arterial wall
  • Collagen fiber
  • Finite deformation
  • Homogenization
  • Micromechanics
  • Soft tissue
  • Variational estimate

ASJC Scopus subject areas

  • Biotechnology
  • Modeling and Simulation
  • Mechanical Engineering

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