Anatomy and physiology of the blood-brain barrier

Yonatan Serlin, Ilan Shelef, Boris Knyazer, Alon Friedman

Research output: Contribution to journalReview articlepeer-review

292 Scopus citations


Essential requisite for the preservation of normal brain activity is to maintain a narrow and stable homeostatic control in the neuronal environment of the CNS. Blood flow alterations and altered vessel permeability are considered key determinants in the pathophysiology of brain injuries. We will review the present-day literature on the anatomy, development and physiological mechanisms of the blood-brain barrier, a distinctive and tightly regulated interface between the CNS and the peripheral circulation, playing a crucial role in the maintenance of the strict environment required for normal brain function.

Original languageEnglish
Pages (from-to)2-6
Number of pages5
JournalSeminars in Cell and Developmental Biology
StatePublished - 1 Feb 2015


  • Blood-brain barrier
  • Neuroglia
  • Neurovascular unit
  • Vessel permeability

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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