Anatomy and physiology of the blood-brain barrier

Yonatan Serlin; Ilan Shelef; Boris Knyazer; Alon Friedman

doi:10.1016/j.semcdb.2015.01.002

Anatomy and physiology of the blood-brain barrier

Yonatan Serlin, Ilan Shelef, Boris Knyazer, Alon Friedman

Department of Physiology and Cell Biology

Research output: Contribution to journal › Review article › peer-review

303 Scopus citations

Abstract

Essential requisite for the preservation of normal brain activity is to maintain a narrow and stable homeostatic control in the neuronal environment of the CNS. Blood flow alterations and altered vessel permeability are considered key determinants in the pathophysiology of brain injuries. We will review the present-day literature on the anatomy, development and physiological mechanisms of the blood-brain barrier, a distinctive and tightly regulated interface between the CNS and the peripheral circulation, playing a crucial role in the maintenance of the strict environment required for normal brain function.

Original language	English
Pages (from-to)	2-6
Number of pages	5
Journal	Seminars in Cell and Developmental Biology
Volume	38
DOIs	https://doi.org/10.1016/j.semcdb.2015.01.002
State	Published - 1 Feb 2015

Keywords

Blood-brain barrier
Neuroglia
Neurovascular unit
Vessel permeability

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.semcdb.2015.01.002

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AU - Shelef, Ilan

AU - Knyazer, Boris

AU - Friedman, Alon

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Y1 - 2015/2/1

N2 - Essential requisite for the preservation of normal brain activity is to maintain a narrow and stable homeostatic control in the neuronal environment of the CNS. Blood flow alterations and altered vessel permeability are considered key determinants in the pathophysiology of brain injuries. We will review the present-day literature on the anatomy, development and physiological mechanisms of the blood-brain barrier, a distinctive and tightly regulated interface between the CNS and the peripheral circulation, playing a crucial role in the maintenance of the strict environment required for normal brain function.

AB - Essential requisite for the preservation of normal brain activity is to maintain a narrow and stable homeostatic control in the neuronal environment of the CNS. Blood flow alterations and altered vessel permeability are considered key determinants in the pathophysiology of brain injuries. We will review the present-day literature on the anatomy, development and physiological mechanisms of the blood-brain barrier, a distinctive and tightly regulated interface between the CNS and the peripheral circulation, playing a crucial role in the maintenance of the strict environment required for normal brain function.

KW - Blood-brain barrier

KW - Neuroglia

KW - Neurovascular unit

KW - Vessel permeability

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JF - Seminars in Cell and Developmental Biology

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Anatomy and physiology of the blood-brain barrier

Abstract

Keywords

ASJC Scopus subject areas

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