And now it starts to get interesting: Gene-gene interactions

Yamima Osher

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


In the beginning, there was the OGOD model: one-gene one-disease.1 Even before the age of molecular genetics, the study of patterns of inheritance made it clear that this model was not applicable to the study of personality traits. When the first replicated reports were published of positive associations between a candidate gene and a personality trait-dopamine D4 receptor gene (D4DR) and novelty seeking (NS)2,3-the authors speculated that that there might be 10 or so different genes, each of small effect size, responsible for the trait.3 The assumption was that the effects of these genes would be additive, each one responsible for about 10% of the observed genetic variance. However, as Richard Ebstein notes in Chapter 18 of this book, finding these genes has proven frustratingly difficult and results are often inconsistent. More recently, evidence has begun to accumulate, which suggests that part of the answer to this conundrum may be found in gene-gene interactions.

Original languageEnglish
Title of host publicationNeurobehavioral Genetics
Subtitle of host publicationMethods and Applications, Second Edition
PublisherCRC Press
Number of pages8
ISBN (Electronic)9781420003567
ISBN (Print)084931903X, 9780849319037
StatePublished - 1 Jan 2006

ASJC Scopus subject areas

  • General Neuroscience
  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


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