Angiotensin ii inhibits Na+/K+ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein

Sayed Modinur Rahaman; Kuntal Dey; Tapati Chakraborti; Sajal Chakraborti

Angiotensin ii inhibits Na⁺/K⁺ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein

Sayed Modinur Rahaman, Kuntal Dey, Tapati Chakraborti, Sajal Chakraborti

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The role of angiotensin II in regulating Na⁺/K⁺-ATPase activity has been investigated in bovine pulmonary artery smooth muscle cells (BPASMCs). Our study reveals that angiotensin II inhibits the Na⁺/K⁺ATPase activity via glutathionylation of the pump with the involvement of an increase in NADPH oxidase-derived O₂^-. Additionally, angiotensin II treatment to the cells increases the inhibitory potency of the 15.6 kDa inhibitor towards the Na⁺/K⁺ATPase activity.

Original language	English
Pages (from-to)	119-124
Number of pages	6
Journal	Indian Journal of Biochemistry and Biophysics
Volume	52
Issue number	2
State	Published - 1 Apr 2015
Externally published	Yes

Keywords

Glutathionylation
Na+/K+-ATPase
Na/KATPase inhibitor
Oxidant
Pulmonary artery smooth muscle cells

ASJC Scopus subject areas

Biophysics
Biochemistry

Cite this

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title = "Angiotensin ii inhibits Na+/K+ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein",

abstract = "The role of angiotensin II in regulating Na+/K+-ATPase activity has been investigated in bovine pulmonary artery smooth muscle cells (BPASMCs). Our study reveals that angiotensin II inhibits the Na+/K+ATPase activity via glutathionylation of the pump with the involvement of an increase in NADPH oxidase-derived O2-. Additionally, angiotensin II treatment to the cells increases the inhibitory potency of the 15.6 kDa inhibitor towards the Na+/K+ATPase activity.",

keywords = "Glutathionylation, Na+/K+-ATPase, Na/KATPase inhibitor, Oxidant, Pulmonary artery smooth muscle cells",

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Angiotensin ii inhibits Na⁺/K⁺ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein. / Rahaman, Sayed Modinur; Dey, Kuntal; Chakraborti, Tapati et al.
In: Indian Journal of Biochemistry and Biophysics, Vol. 52, No. 2, 01.04.2015, p. 119-124.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Angiotensin ii inhibits Na+/K+ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein

AU - Rahaman, Sayed Modinur

AU - Dey, Kuntal

AU - Chakraborti, Tapati

AU - Chakraborti, Sajal

PY - 2015/4/1

Y1 - 2015/4/1

N2 - The role of angiotensin II in regulating Na+/K+-ATPase activity has been investigated in bovine pulmonary artery smooth muscle cells (BPASMCs). Our study reveals that angiotensin II inhibits the Na+/K+ATPase activity via glutathionylation of the pump with the involvement of an increase in NADPH oxidase-derived O2-. Additionally, angiotensin II treatment to the cells increases the inhibitory potency of the 15.6 kDa inhibitor towards the Na+/K+ATPase activity.

AB - The role of angiotensin II in regulating Na+/K+-ATPase activity has been investigated in bovine pulmonary artery smooth muscle cells (BPASMCs). Our study reveals that angiotensin II inhibits the Na+/K+ATPase activity via glutathionylation of the pump with the involvement of an increase in NADPH oxidase-derived O2-. Additionally, angiotensin II treatment to the cells increases the inhibitory potency of the 15.6 kDa inhibitor towards the Na+/K+ATPase activity.

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KW - Na+/K+-ATPase

KW - Na/KATPase inhibitor

KW - Oxidant

KW - Pulmonary artery smooth muscle cells

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Angiotensin ii inhibits Na⁺/K⁺ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein

Abstract

Keywords

ASJC Scopus subject areas

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