Animal models of depression and anxiety: What do they tell us about human condition?

I. D. Neumann; G. Wegener; J. R. Homberg; H. Cohen; D. A. Slattery; J. Zohar; J. D.A. Olivier; A. Mathé

doi:10.1016/j.pnpbp.2010.11.028

Animal models of depression and anxiety: What do they tell us about human condition?

I. D. Neumann, G. Wegener, J. R. Homberg, H. Cohen, D. A. Slattery, J. Zohar, J. D.A. Olivier, A. Mathé

Research output: Contribution to journal › Short survey › peer-review

115 Scopus citations

Abstract

While modern neurobiology methods are necessary they are not sufficient to elucidate etiology and pathophysiology of affective disorders and develop new treatments. Achievement of these goals is contingent on applying cutting edge methods on appropriate disease models. In this review, the authors present four rodent models with good face-, construct-, and predictive-validity: the Flinders Sensitive rat line (FSL); the genetically "anxious" High Anxiety-like Behavior (HAB) line; the serotonin transporter knockout 5-HTT ^-/- rat and mouse lines; and the post-traumatic stress disorder (PTSD) model induced by exposure to predator scent, that they have employed to investigate the nature of depression and anxiety.

Original language	English
Pages (from-to)	1357-1375
Number of pages	19
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	35
Issue number	6
DOIs	https://doi.org/10.1016/j.pnpbp.2010.11.028
State	Published - 1 Aug 2011

Keywords

Animal models
Anxiety
Depression
PTSD
Translational

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/j.pnpbp.2010.11.028

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title = "Animal models of depression and anxiety: What do they tell us about human condition?",

abstract = "While modern neurobiology methods are necessary they are not sufficient to elucidate etiology and pathophysiology of affective disorders and develop new treatments. Achievement of these goals is contingent on applying cutting edge methods on appropriate disease models. In this review, the authors present four rodent models with good face-, construct-, and predictive-validity: the Flinders Sensitive rat line (FSL); the genetically {"}anxious{"} High Anxiety-like Behavior (HAB) line; the serotonin transporter knockout 5-HTT -/- rat and mouse lines; and the post-traumatic stress disorder (PTSD) model induced by exposure to predator scent, that they have employed to investigate the nature of depression and anxiety.",

keywords = "Animal models, Anxiety, Depression, PTSD, Translational",

author = "Neumann, {I. D.} and G. Wegener and Homberg, {J. R.} and H. Cohen and Slattery, {D. A.} and J. Zohar and Olivier, {J. D.A.} and A. Math{\'e}",

note = "Funding Information: We are grateful for funding from the BMBF and Deutsche Forschungsgemeinschaft (Germany, IDN), the Swedish Medical Research Council (grant 1041 ) and the Karolinska Institutet (AAM), the National Institute for Psychobiology in Israel, funded by Charles E. Smith Family , the Israel Academy of Science and Humanities grant (# 416/09 ) and the Ministry of Health grant (# 6086 , HC), the Danish Medical Research Council (Grant 271-08-0768 ) and the Research Foundation of County Midtjylland (GW), and the Netherlands Organisation for Scientific Research (NWO) (grant # 819.02.022 ). We thank Mr. Sebastian Peters for substantial editorial help.",

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T2 - What do they tell us about human condition?

AU - Neumann, I. D.

AU - Wegener, G.

AU - Homberg, J. R.

AU - Cohen, H.

AU - Slattery, D. A.

AU - Zohar, J.

AU - Olivier, J. D.A.

AU - Mathé, A.

N1 - Funding Information: We are grateful for funding from the BMBF and Deutsche Forschungsgemeinschaft (Germany, IDN), the Swedish Medical Research Council (grant 1041 ) and the Karolinska Institutet (AAM), the National Institute for Psychobiology in Israel, funded by Charles E. Smith Family , the Israel Academy of Science and Humanities grant (# 416/09 ) and the Ministry of Health grant (# 6086 , HC), the Danish Medical Research Council (Grant 271-08-0768 ) and the Research Foundation of County Midtjylland (GW), and the Netherlands Organisation for Scientific Research (NWO) (grant # 819.02.022 ). We thank Mr. Sebastian Peters for substantial editorial help.

PY - 2011/8/1

Y1 - 2011/8/1

N2 - While modern neurobiology methods are necessary they are not sufficient to elucidate etiology and pathophysiology of affective disorders and develop new treatments. Achievement of these goals is contingent on applying cutting edge methods on appropriate disease models. In this review, the authors present four rodent models with good face-, construct-, and predictive-validity: the Flinders Sensitive rat line (FSL); the genetically "anxious" High Anxiety-like Behavior (HAB) line; the serotonin transporter knockout 5-HTT -/- rat and mouse lines; and the post-traumatic stress disorder (PTSD) model induced by exposure to predator scent, that they have employed to investigate the nature of depression and anxiety.

AB - While modern neurobiology methods are necessary they are not sufficient to elucidate etiology and pathophysiology of affective disorders and develop new treatments. Achievement of these goals is contingent on applying cutting edge methods on appropriate disease models. In this review, the authors present four rodent models with good face-, construct-, and predictive-validity: the Flinders Sensitive rat line (FSL); the genetically "anxious" High Anxiety-like Behavior (HAB) line; the serotonin transporter knockout 5-HTT -/- rat and mouse lines; and the post-traumatic stress disorder (PTSD) model induced by exposure to predator scent, that they have employed to investigate the nature of depression and anxiety.

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Animal models of depression and anxiety: What do they tell us about human condition?

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Keywords

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