TY - JOUR
T1 - Anisotropy of transverse spin relaxation in H2O-D2O liquid entrapped in Nanocavities
T2 - application to studies of connective tissues
AU - Furman, Gregory
AU - Meerovich, Victor
AU - Petrov, Danil
AU - Sokolovsky, Vladimir
AU - Xia, Yang
N1 - Funding Information:
This research was supported by a grant from the United States - Israel Binational Science Foundation (BSF), Jerusalem, Israel (No. 2019033), and by a grant from the National Institutes of Health in the United States (AR 069047). The authors are grateful to Dr. K. I. Momot for helpful discussions.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - The spin-spin relaxation in connective tissues is simulated using a model in which the tissue is represented by a set of nanocavities containing H2O-D2O liquid. Collagen fibrils in connective tissues form ordered hierarchical long structures of hydrated nano-cavities with characteristic diameter from 1 nm to several tens of nanometers and length of about 100 nm. We consider influence of the restricted Brownian motion of molecules inside a nano-cavity on spin-spin relaxation. The analytical expression for the transverse time T2 for H2O-D2O the liquid in contained a nanocavity was obtained. We show that the angular dependence of the transverse relaxation rate does not depend on the concentration of D2O. The theoretical results could explain the experimentally observed dependence of the degree of deuteration on the relaxation time T2. Accounting the orientation distribution of the nanocavities well agreement with the experimental dependence of the relaxation for articular cartilage on the deuteration degree was obtained.
AB - The spin-spin relaxation in connective tissues is simulated using a model in which the tissue is represented by a set of nanocavities containing H2O-D2O liquid. Collagen fibrils in connective tissues form ordered hierarchical long structures of hydrated nano-cavities with characteristic diameter from 1 nm to several tens of nanometers and length of about 100 nm. We consider influence of the restricted Brownian motion of molecules inside a nano-cavity on spin-spin relaxation. The analytical expression for the transverse time T2 for H2O-D2O the liquid in contained a nanocavity was obtained. We show that the angular dependence of the transverse relaxation rate does not depend on the concentration of D2O. The theoretical results could explain the experimentally observed dependence of the degree of deuteration on the relaxation time T2. Accounting the orientation distribution of the nanocavities well agreement with the experimental dependence of the relaxation for articular cartilage on the deuteration degree was obtained.
KW - Anisotropy of transverse spin relaxation
KW - Deuteration, bovine articular cartilage
KW - Deuterium oxide
KW - Dipole–dipole interactions
KW - Nanocavity
UR - http://www.scopus.com/inward/record.url?scp=85118241126&partnerID=8YFLogxK
U2 - 10.1007/s10751-021-01731-9
DO - 10.1007/s10751-021-01731-9
M3 - Article
C2 - 35990926
AN - SCOPUS:85118241126
SN - 0304-3843
VL - 242
JO - Hyperfine Interactions
JF - Hyperfine Interactions
IS - 1
M1 - 19
ER -