TY - JOUR
T1 - Antenatal diagnosis of idiopathic arterial calcification
T2 - a systematic review with a report of two cases
AU - Mastrolia, Salvatore Andrea
AU - Weintraub, Adi Yekuda
AU - Baron, Joel
AU - Sciaky-Tamir, Yael
AU - Koifman, Arie
AU - Loverro, Giuseppe
AU - Hershkovitz, Reli
N1 - Publisher Copyright:
© 2014, Springer-Verlag Berlin Heidelberg.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Introduction: Idiopathic antenatal calcification is a rare, generally lethal, condition with unclear etiology.Materials and methods: Around 200 cases, most of them undergoing postnatal diagnosis, are reported in literature. The majority of the affected infants die before the age of 6 months, and very few have survived for more than 1 year. Five cases of spontaneous resolution of the disease are described.Discussion: An autosomal recessive pattern of inheritance has been suggested for this condition, with some gene mutations which have been recently discovered. Therapy with bisphosphonates has been suggested, with conflicting evidence regarding the utility in the regression of the disease.Conclusion: The main purpose of the present report is to provide the available knowledge on this subject through a systematic review of the literature. In addition, we describe two cases of antenatal idiopathic arterial calcification in which antenatal diagnosis was achieved.
AB - Introduction: Idiopathic antenatal calcification is a rare, generally lethal, condition with unclear etiology.Materials and methods: Around 200 cases, most of them undergoing postnatal diagnosis, are reported in literature. The majority of the affected infants die before the age of 6 months, and very few have survived for more than 1 year. Five cases of spontaneous resolution of the disease are described.Discussion: An autosomal recessive pattern of inheritance has been suggested for this condition, with some gene mutations which have been recently discovered. Therapy with bisphosphonates has been suggested, with conflicting evidence regarding the utility in the regression of the disease.Conclusion: The main purpose of the present report is to provide the available knowledge on this subject through a systematic review of the literature. In addition, we describe two cases of antenatal idiopathic arterial calcification in which antenatal diagnosis was achieved.
KW - Bisphosphonate therapy
KW - Fetal demise
KW - Fetal hydrops
KW - Heart failure
UR - http://www.scopus.com/inward/record.url?scp=84925518126&partnerID=8YFLogxK
U2 - 10.1007/s00404-014-3567-z
DO - 10.1007/s00404-014-3567-z
M3 - Review article
C2 - 25524533
AN - SCOPUS:84925518126
SN - 0932-0067
VL - 291
SP - 977
EP - 986
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
IS - 5
ER -
