Anti-heparan sulfate antibodies in neurological disease

Chiara Briani, Susanna Ruggero, Armin Alaedini, Ettore Nardelli, Sergio Ferrari, Itzhak Wirguin, Gabriella Zara, Leontino Battistin, Norman Latov

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Antibodies to heparan sulfate (HS) have previously been found in association with peripheral neuropathy. We tested sera from patients with neuropathies and with other neurological diseases for antibodies to HS using an avidin-biotin enzyme-linked immunosorbent assay (ELISA) system. Increased titers of anti-HS antibodies were found in 3.4% of patients with neuropathy, and in 3% of patients with other neurological diseases. In all cases, however, an inflammatory disease was present, including chronic inflammatory neuropathy, cerebral vasculitis, or multiple sclerosis. Antibodies to HS appear not to be specific for neuropathy, as they occur in several inflammatory diseases. They might contribute to the associated breakdown of the blood-brain or blood-nerve barrier.

Original languageEnglish
Pages (from-to)713-715
Number of pages3
JournalMuscle and Nerve
Issue number5
StatePublished - 1 Nov 2002
Externally publishedYes


  • Antibody
  • Glycosaminoglycans
  • Heparan sulfate
  • Neuropathy
  • Vasculitis

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


Dive into the research topics of 'Anti-heparan sulfate antibodies in neurological disease'. Together they form a unique fingerprint.

Cite this