Antiangiogenic naphthalene sulfonic distamycin-A derivatives tightly interact with human basic fibroblast growth factor

Moreno Zamai; Abraham H. Parola; Maria Grandi; Nicola Mongelli; Valeria R. Caiolfa

Antiangiogenic naphthalene sulfonic distamycin-A derivatives tightly interact with human basic fibroblast growth factor

Moreno Zamai, Abraham H. Parola, Maria Grandi, Nicola Mongelli, Valeria R. Caiolfa

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A novel class of non-cytotoxic synthetic sulfonated distamycin A derivatives (suradistas) was shown to have anti-angiogenic activity in vitro and in vivo. The in vivo antitumor activity is probably due to the growth factor binding properties of these molecules. Three of them were spectroscopically characterized. For the first time, their direct interaction with human recombinant basic fibroblast growth factor was proved by means of steady-state fluorescence anisotropy and equilibrium affinity chromatography. Suradista:bFGF complexes had dissociation constants in the range of 10 ^-6-10 ^-7 M.

Original language	English
Pages (from-to)	36-44
Number of pages	9
Journal	Medicinal Chemistry Research
Volume	7
Issue number	1
State	Published - 1 Dec 1997

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics (all)
Organic Chemistry

Cite this

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title = "Antiangiogenic naphthalene sulfonic distamycin-A derivatives tightly interact with human basic fibroblast growth factor",

abstract = "A novel class of non-cytotoxic synthetic sulfonated distamycin A derivatives (suradistas) was shown to have anti-angiogenic activity in vitro and in vivo. The in vivo antitumor activity is probably due to the growth factor binding properties of these molecules. Three of them were spectroscopically characterized. For the first time, their direct interaction with human recombinant basic fibroblast growth factor was proved by means of steady-state fluorescence anisotropy and equilibrium affinity chromatography. Suradista:bFGF complexes had dissociation constants in the range of 10 -6-10 -7 M.",

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year = "1997",

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language = "English",

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journal = "Medicinal Chemistry Research",

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T1 - Antiangiogenic naphthalene sulfonic distamycin-A derivatives tightly interact with human basic fibroblast growth factor

AU - Zamai, Moreno

AU - Parola, Abraham H.

AU - Grandi, Maria

AU - Mongelli, Nicola

AU - Caiolfa, Valeria R.

PY - 1997/12/1

Y1 - 1997/12/1

N2 - A novel class of non-cytotoxic synthetic sulfonated distamycin A derivatives (suradistas) was shown to have anti-angiogenic activity in vitro and in vivo. The in vivo antitumor activity is probably due to the growth factor binding properties of these molecules. Three of them were spectroscopically characterized. For the first time, their direct interaction with human recombinant basic fibroblast growth factor was proved by means of steady-state fluorescence anisotropy and equilibrium affinity chromatography. Suradista:bFGF complexes had dissociation constants in the range of 10 -6-10 -7 M.

AB - A novel class of non-cytotoxic synthetic sulfonated distamycin A derivatives (suradistas) was shown to have anti-angiogenic activity in vitro and in vivo. The in vivo antitumor activity is probably due to the growth factor binding properties of these molecules. Three of them were spectroscopically characterized. For the first time, their direct interaction with human recombinant basic fibroblast growth factor was proved by means of steady-state fluorescence anisotropy and equilibrium affinity chromatography. Suradista:bFGF complexes had dissociation constants in the range of 10 -6-10 -7 M.

UR - http://www.scopus.com/inward/record.url?scp=0002053270&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0002053270

SN - 1054-2523

VL - 7

SP - 36

EP - 44

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 1

ER -

Antiangiogenic naphthalene sulfonic distamycin-A derivatives tightly interact with human basic fibroblast growth factor

Abstract

ASJC Scopus subject areas

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