A novel class of non-cytotoxic synthetic sulfonated distamycin A derivatives (suradistas) was shown to have anti-angiogenic activity in vitro and in vivo. The in vivo antitumor activity is probably due to the growth factor binding properties of these molecules. Three of them were spectroscopically characterized. For the first time, their direct interaction with human recombinant basic fibroblast growth factor was proved by means of steady-state fluorescence anisotropy and equilibrium affinity chromatography. Suradista:bFGF complexes had dissociation constants in the range of 10 -6-10 -7 M.
|Number of pages||9|
|Journal||Medicinal Chemistry Research|
|State||Published - 1 Dec 1997|