Antibiotic treatment in acute otitis media: 'In vivo' demonstration of antibacterial activity

Ron Dagan; Dan M. Fliss; Eugene Leibovitz; Oren Abramson; David Greenberg; Ruth Lang; Swan Goshen; Pablo Yagupsky; Alberto Leiberman

doi:10.1016/s1198-743x(14)64952-1

Antibiotic treatment in acute otitis media: 'In vivo' demonstration of antibacterial activity

Ron Dagan, Dan M. Fliss, Eugene Leibovitz, Oren Abramson, David Greenberg, Ruth Lang, Swan Goshen, Pablo Yagupsky, Alberto Leiberman

The Shraga Segal Department of Microbiology and Immunology

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

The ultimate goal in antibiotic treatment of acute otitis media (AOM) is eradication of the pathogens from the middle ear fluid (MEF). To test the ability of an antibiotic to achieve this goal, the best available method is to obtain MEF by aspiration before initiating antibiotics and to repeat this procedure during treatment, a method which was termed the 'in vivo sensitivity test'. This advantageous method is difficult to perform and thus only a few groups were able to conduct such large-scale studies. The available information is discussed in the present manuscript, as well as some preliminary results suggesting that oral β-lactam antibiotics may not be the ideal drugs to date, due to the emergence of resistant pneumococci.

Original language	English
Pages (from-to)	3S43-3S48
Journal	Clinical Microbiology and Infection
Volume	3
Issue number	SUPPL. 3
DOIs	https://doi.org/10.1016/s1198-743x(14)64952-1
State	Published - 1 Jan 1997

Keywords

Antibiotic treatment
Bacteriology
Otitis media

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/s1198-743x(14)64952-1

Cite this

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title = "Antibiotic treatment in acute otitis media: 'In vivo' demonstration of antibacterial activity",

abstract = "The ultimate goal in antibiotic treatment of acute otitis media (AOM) is eradication of the pathogens from the middle ear fluid (MEF). To test the ability of an antibiotic to achieve this goal, the best available method is to obtain MEF by aspiration before initiating antibiotics and to repeat this procedure during treatment, a method which was termed the 'in vivo sensitivity test'. This advantageous method is difficult to perform and thus only a few groups were able to conduct such large-scale studies. The available information is discussed in the present manuscript, as well as some preliminary results suggesting that oral β-lactam antibiotics may not be the ideal drugs to date, due to the emergence of resistant pneumococci.",

keywords = "Antibiotic treatment, Bacteriology, Otitis media",

author = "Ron Dagan and Fliss, {Dan M.} and Eugene Leibovitz and Oren Abramson and David Greenberg and Ruth Lang and Swan Goshen and Pablo Yagupsky and Alberto Leiberman",

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T1 - Antibiotic treatment in acute otitis media

T2 - 'In vivo' demonstration of antibacterial activity

AU - Dagan, Ron

AU - Fliss, Dan M.

AU - Leibovitz, Eugene

AU - Abramson, Oren

AU - Greenberg, David

AU - Lang, Ruth

AU - Goshen, Swan

AU - Yagupsky, Pablo

AU - Leiberman, Alberto

PY - 1997/1/1

Y1 - 1997/1/1

N2 - The ultimate goal in antibiotic treatment of acute otitis media (AOM) is eradication of the pathogens from the middle ear fluid (MEF). To test the ability of an antibiotic to achieve this goal, the best available method is to obtain MEF by aspiration before initiating antibiotics and to repeat this procedure during treatment, a method which was termed the 'in vivo sensitivity test'. This advantageous method is difficult to perform and thus only a few groups were able to conduct such large-scale studies. The available information is discussed in the present manuscript, as well as some preliminary results suggesting that oral β-lactam antibiotics may not be the ideal drugs to date, due to the emergence of resistant pneumococci.

AB - The ultimate goal in antibiotic treatment of acute otitis media (AOM) is eradication of the pathogens from the middle ear fluid (MEF). To test the ability of an antibiotic to achieve this goal, the best available method is to obtain MEF by aspiration before initiating antibiotics and to repeat this procedure during treatment, a method which was termed the 'in vivo sensitivity test'. This advantageous method is difficult to perform and thus only a few groups were able to conduct such large-scale studies. The available information is discussed in the present manuscript, as well as some preliminary results suggesting that oral β-lactam antibiotics may not be the ideal drugs to date, due to the emergence of resistant pneumococci.

KW - Antibiotic treatment

KW - Bacteriology

KW - Otitis media

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U2 - 10.1016/s1198-743x(14)64952-1

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M3 - Review article

AN - SCOPUS:0030852953

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SP - 3S43-3S48

JO - Clinical Microbiology and Infection

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IS - SUPPL. 3

ER -

Antibiotic treatment in acute otitis media: 'In vivo' demonstration of antibacterial activity

Abstract

Keywords

ASJC Scopus subject areas

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