Antibody pattern to human cytomegalovirus in patients with adenocarcinoma of the colon

Arie Avni, Hava Haikin, Moshe M. Feuchtwanger, Martin Sacks, Lechaim Naggan, Balia Sarov, Israel Sarov

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations


    The role of human cytomegalovirus (CMV) was examined according to serological patterns in 37 patients with adenocarcinoma of the colon (ACC). The sera were examined for the presence of IgG antibodies by the immunoperoxidase antibody to membrane antigen (IPAMA) method and by the complement-fixation (CF) test. Antibody determinations were also performed by the IPAMA method for three other members of the herpesvirus group: Epstein-Barr virus (EBV), herpes simplex virus (HSV) and varicella-zoster virus (VZV). Comparison groups included normal subjects, ACC patients treated with chemotherapy, and patients operated on for benign diseases. No significant difference was found in the geometric mean titers (GMTs) for CMV and the other herpesviruses in the sera of nontreated ACC patients when compared with the control groups. However, a significantly elevated antibody titer to CMV was found in chemotherapy-treated ACC patients by both the IPAMA and CF methods. In this group, elevated titers were found by the IPAMA method for EBV and HSV, but not for VZV. The significance of serological studies in elucidating the role of CMV in ACC patients is discussed.

    Original languageEnglish
    Pages (from-to)244-249
    Number of pages6
    Issue number4
    StatePublished - 1 Jan 1981


    • Adenocarcinoma of the colon
    • Cytomegalovirus

    ASJC Scopus subject areas

    • Virology
    • Infectious Diseases


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