TY - JOUR
T1 - Anticancer Applications and Pharmacological Properties of Piperidine and Piperine
T2 - A Comprehensive Review on Molecular Mechanisms and Therapeutic Perspectives
AU - Mitra, Sicon
AU - Anand, Uttpal
AU - Jha, Niraj Kumar
AU - Shekhawat, Mahipal S.
AU - Saha, Suchismita Chatterjee
AU - Nongdam, Potshangbam
AU - Rengasamy, Kannan R.R.
AU - Proćków, Jarosław
AU - Dey, Abhijit
N1 - Publisher Copyright:
Copyright © 2022 Mitra, Anand, Jha, Shekhawat, Saha, Nongdam, Rengasamy, Proćków and Dey.
PY - 2022/1/7
Y1 - 2022/1/7
N2 - Piperine and piperidine are the two major alkaloids extracted from black pepper (Piper nigrum); piperidine is a heterocyclic moiety that has the molecular formula (CH2)5NH. Over the years, many therapeutic properties including anticancer potential of these two compounds have been observed. Piperine has therapeutic potential against cancers such as breast cancer, ovarian cancer, gastric cancer, gliomal cancer, lung cancer, oral squamous, chronic pancreatitis, prostate cancer, rectal cancer, cervical cancer, and leukemia. Whereas, piperidine acts as a potential clinical agent against cancers, such as breast cancer, prostate cancer, colon cancer, lung cancer, and ovarian cancer, when treated alone or in combination with some novel drugs. Several crucial signalling pathways essential for the establishment of cancers such as STAT-3, NF-κB, PI3k/Aκt, JNK/p38-MAPK, TGF-ß/SMAD, Smac/DIABLO, p-IκB etc., are regulated by these two phytochemicals. Both of these phytochemicals lead to inhibition of cell migration and help in cell cycle arrest to inhibit survivability of cancer cells. The current review highlights the pharmaceutical relevance of both piperine and piperidine against different types of cancers.
AB - Piperine and piperidine are the two major alkaloids extracted from black pepper (Piper nigrum); piperidine is a heterocyclic moiety that has the molecular formula (CH2)5NH. Over the years, many therapeutic properties including anticancer potential of these two compounds have been observed. Piperine has therapeutic potential against cancers such as breast cancer, ovarian cancer, gastric cancer, gliomal cancer, lung cancer, oral squamous, chronic pancreatitis, prostate cancer, rectal cancer, cervical cancer, and leukemia. Whereas, piperidine acts as a potential clinical agent against cancers, such as breast cancer, prostate cancer, colon cancer, lung cancer, and ovarian cancer, when treated alone or in combination with some novel drugs. Several crucial signalling pathways essential for the establishment of cancers such as STAT-3, NF-κB, PI3k/Aκt, JNK/p38-MAPK, TGF-ß/SMAD, Smac/DIABLO, p-IκB etc., are regulated by these two phytochemicals. Both of these phytochemicals lead to inhibition of cell migration and help in cell cycle arrest to inhibit survivability of cancer cells. The current review highlights the pharmaceutical relevance of both piperine and piperidine against different types of cancers.
KW - anti-breast cancer
KW - anti-gastric cancer
KW - anti-ovarian effect
KW - anti-prostate cancer
KW - mechanism of action
KW - piper
KW - piperidine
KW - piperine
UR - http://www.scopus.com/inward/record.url?scp=85123212956&partnerID=8YFLogxK
U2 - 10.3389/fphar.2021.772418
DO - 10.3389/fphar.2021.772418
M3 - Review article
C2 - 35069196
AN - SCOPUS:85123212956
SN - 1663-9812
VL - 12
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 772418
ER -