Anticancer potential of oroxylin A: from mechanistic insight to synergistic perspectives

Hardeep Singh Tuli, Vivek Kumar Garg, Ajay Kumar, Diwakar Aggarwal, Uttpal Anand, Nidarshana Chaturvedi Parashar, Adesh K. Saini, Ranjan K. Mohapatra, Kuldeep Dhama, Manoj Kumar, Tejveer Singh, Jagjit Kaur, Katrin Sak

Research output: Contribution to journalReview articlepeer-review

Abstract

Oroxylin A (OA), a well-known constituent of the root of Scutellariae plants, has been used in ethnomedicine already for centuries in treating various neoplastic disorders. However, only recent molecular studies have revealed the different mechanisms behind its action, demonstrating antiproliferative, anti-inflammatory, and proapoptotic effects, restricting also the spread of cancer cells to distant organs. A variety of cellular targets and modulated signal transduction pathways regulated by OA have been determined in diverse cells derived from different malignant tissues. In this review article, these anticancer activities are thoroughly described, representing OA as a potential lead structure for the design of novel more potent anticancer medicines. In addition, co-effects of this natural compound with conventional anticancer agents are analyzed and the advantages provided by nanotechnological methods for more efficient application of OA are discussed. In this way, OA might represent an excellent example of using ethnopharmacological knowledge for designing modern medicines.

Original languageEnglish
Pages (from-to)191-212
Number of pages22
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume396
Issue number2
DOIs
StateAccepted/In press - 1 Jan 2022

Keywords

  • Anti-inflammatory
  • Anti-neoplastic
  • Cancer
  • Flavonoids
  • Oroxylin-A

ASJC Scopus subject areas

  • Pharmacology

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