TY - JOUR
T1 - Anticancer potential of oroxylin A
T2 - from mechanistic insight to synergistic perspectives
AU - Tuli, Hardeep Singh
AU - Garg, Vivek Kumar
AU - Kumar, Ajay
AU - Aggarwal, Diwakar
AU - Anand, Uttpal
AU - Parashar, Nidarshana Chaturvedi
AU - Saini, Adesh K.
AU - Mohapatra, Ranjan K.
AU - Dhama, Kuldeep
AU - Kumar, Manoj
AU - Singh, Tejveer
AU - Kaur, Jagjit
AU - Sak, Katrin
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Oroxylin A (OA), a well-known constituent of the root of Scutellariae plants, has been used in ethnomedicine already for centuries in treating various neoplastic disorders. However, only recent molecular studies have revealed the different mechanisms behind its action, demonstrating antiproliferative, anti-inflammatory, and proapoptotic effects, restricting also the spread of cancer cells to distant organs. A variety of cellular targets and modulated signal transduction pathways regulated by OA have been determined in diverse cells derived from different malignant tissues. In this review article, these anticancer activities are thoroughly described, representing OA as a potential lead structure for the design of novel more potent anticancer medicines. In addition, co-effects of this natural compound with conventional anticancer agents are analyzed and the advantages provided by nanotechnological methods for more efficient application of OA are discussed. In this way, OA might represent an excellent example of using ethnopharmacological knowledge for designing modern medicines.
AB - Oroxylin A (OA), a well-known constituent of the root of Scutellariae plants, has been used in ethnomedicine already for centuries in treating various neoplastic disorders. However, only recent molecular studies have revealed the different mechanisms behind its action, demonstrating antiproliferative, anti-inflammatory, and proapoptotic effects, restricting also the spread of cancer cells to distant organs. A variety of cellular targets and modulated signal transduction pathways regulated by OA have been determined in diverse cells derived from different malignant tissues. In this review article, these anticancer activities are thoroughly described, representing OA as a potential lead structure for the design of novel more potent anticancer medicines. In addition, co-effects of this natural compound with conventional anticancer agents are analyzed and the advantages provided by nanotechnological methods for more efficient application of OA are discussed. In this way, OA might represent an excellent example of using ethnopharmacological knowledge for designing modern medicines.
KW - Anti-inflammatory
KW - Anti-neoplastic
KW - Cancer
KW - Flavonoids
KW - Oroxylin-A
UR - http://www.scopus.com/inward/record.url?scp=85139695123&partnerID=8YFLogxK
U2 - 10.1007/s00210-022-02298-0
DO - 10.1007/s00210-022-02298-0
M3 - Review article
C2 - 36214865
AN - SCOPUS:85139695123
SN - 0028-1298
VL - 396
SP - 191
EP - 212
JO - Naunyn-Schmiedeberg's Archives of Pharmacology
JF - Naunyn-Schmiedeberg's Archives of Pharmacology
IS - 2
ER -