Anticoagulant therapy and thromboprophylaxis in patients with thrombophilia

Adi Y. Weintraub, Eyal Sheiner

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Objective: The aim of this review was to discuss the effectiveness of anticoagulant therapy and thromboprophylaxis in patients with thrombophilia. Methods: A MEDLINE search was performed using the keywords: "anticoagulant therapy", "pregnancy", "thromboprophylaxis", "thrombophilia", "adverse pregnancy outcomes", "venous thromboembolism", "heparin" and "low molecular weight heparin". Results: The identification of a link between thrombophilic factors and adverse pregnancy outcome offers treatment possibilities. Until recently, it has not been clear whether antithrombotic therapy is useful in women with previous placental dysfunction and inherited thrombophilia. Anticoagulant therapy is indicated during pregnancy for the prevention and treatment of venous thromboembolism, for the prevention and treatment of systemic embolism in patients with mechanical heart valves and, for the prevention of pregnancy complications in women with antiphospholipid antibody syndrome or other thrombophilic disorders and previous pregnancy complications. At present, limited data exist regarding the efficacy of anticoagulants during pregnancy. Recommendations are largely based on data extrapolated from non-pregnant patients, case reports, and case series of pregnant patients. Many physicians have been treating such women with antithrombotic therapy on the basis of logic and anecdotal evidence. Conclusion: A regimen for thrombophylaxis and treatment of thrombophilic parturient based on thrombophilia type is proposed.

Original languageEnglish
Pages (from-to)567-571
Number of pages5
JournalArchives of Gynecology and Obstetrics
Issue number6
StatePublished - 1 Dec 2007
Externally publishedYes


  • Anticoagulant therapy
  • Low molecular weight heparin
  • Thrombophilia
  • Thromboprophylaxis
  • Venous thromboembolism

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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