Antimalarial interaction of quinine and quinidine with clarithromycin

Swaroop Kumar Pandey; Hemlata Dwivedi; Sarika Singh; Waseem Ahmad Siddiqui; Renu Tripathi

doi:10.1017/S003118201200176X

Antimalarial interaction of quinine and quinidine with clarithromycin

Swaroop Kumar Pandey, Hemlata Dwivedi, Sarika Singh, Waseem Ahmad Siddiqui, Renu Tripathi

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Quinine (QN) and quinidine (QND) have been commonly used as effective and affordable antimalarials for over many years. Quinine primarily is used for severe malaria treatment. However, plasmodia resistance to these drugs and poor patient compliance limits their administration to the patients. The declining sensitivity of the parasite to the drugs can thus be dealt with by combining with a suitable partner drug. In the present study QN/QND was assessed in combination with clarithromycin (CLTR), an antibiotic of the macrolide family. In vitro interactions of these drugs with CLTR against Plasmodium falciparum (P. falciparum) have shown a synergistic response with mean sum fractional inhibitory concentrations (ΣFICs) of â

Original language	English
Pages (from-to)	406-413
Number of pages	8
Journal	Parasitology
Volume	140
Issue number	3
DOIs	https://doi.org/10.1017/S003118201200176X
State	Published - 1 Mar 2013
Externally published	Yes

Keywords

clarithromycin
drug resistance
malaria
quinidine
quinine

ASJC Scopus subject areas

Parasitology
Animal Science and Zoology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/S003118201200176X

Cite this

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abstract = "Quinine (QN) and quinidine (QND) have been commonly used as effective and affordable antimalarials for over many years. Quinine primarily is used for severe malaria treatment. However, plasmodia resistance to these drugs and poor patient compliance limits their administration to the patients. The declining sensitivity of the parasite to the drugs can thus be dealt with by combining with a suitable partner drug. In the present study QN/QND was assessed in combination with clarithromycin (CLTR), an antibiotic of the macrolide family. In vitro interactions of these drugs with CLTR against Plasmodium falciparum (P. falciparum) have shown a synergistic response with mean sum fractional inhibitory concentrations (ΣFICs) of {\^a}",

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T1 - Antimalarial interaction of quinine and quinidine with clarithromycin

AU - Pandey, Swaroop Kumar

AU - Dwivedi, Hemlata

AU - Singh, Sarika

AU - Siddiqui, Waseem Ahmad

AU - Tripathi, Renu

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Quinine (QN) and quinidine (QND) have been commonly used as effective and affordable antimalarials for over many years. Quinine primarily is used for severe malaria treatment. However, plasmodia resistance to these drugs and poor patient compliance limits their administration to the patients. The declining sensitivity of the parasite to the drugs can thus be dealt with by combining with a suitable partner drug. In the present study QN/QND was assessed in combination with clarithromycin (CLTR), an antibiotic of the macrolide family. In vitro interactions of these drugs with CLTR against Plasmodium falciparum (P. falciparum) have shown a synergistic response with mean sum fractional inhibitory concentrations (ΣFICs) of â

AB - Quinine (QN) and quinidine (QND) have been commonly used as effective and affordable antimalarials for over many years. Quinine primarily is used for severe malaria treatment. However, plasmodia resistance to these drugs and poor patient compliance limits their administration to the patients. The declining sensitivity of the parasite to the drugs can thus be dealt with by combining with a suitable partner drug. In the present study QN/QND was assessed in combination with clarithromycin (CLTR), an antibiotic of the macrolide family. In vitro interactions of these drugs with CLTR against Plasmodium falciparum (P. falciparum) have shown a synergistic response with mean sum fractional inhibitory concentrations (ΣFICs) of â

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KW - drug resistance

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Antimalarial interaction of quinine and quinidine with clarithromycin

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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