Antimalarial interaction of quinine and quinidine with clarithromycin

Swaroop Kumar Pandey, Hemlata Dwivedi, Sarika Singh, Waseem Ahmad Siddiqui, Renu Tripathi

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Quinine (QN) and quinidine (QND) have been commonly used as effective and affordable antimalarials for over many years. Quinine primarily is used for severe malaria treatment. However, plasmodia resistance to these drugs and poor patient compliance limits their administration to the patients. The declining sensitivity of the parasite to the drugs can thus be dealt with by combining with a suitable partner drug. In the present study QN/QND was assessed in combination with clarithromycin (CLTR), an antibiotic of the macrolide family. In vitro interactions of these drugs with CLTR against Plasmodium falciparum (P. falciparum) have shown a synergistic response with mean sum fractional inhibitory concentrations (ΣFICs) of â

Original languageEnglish
Pages (from-to)406-413
Number of pages8
Issue number3
StatePublished - 1 Mar 2013
Externally publishedYes


  • clarithromycin
  • drug resistance
  • malaria
  • quinidine
  • quinine

ASJC Scopus subject areas

  • Parasitology
  • Animal Science and Zoology
  • Infectious Diseases


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