Antimicrobial hydrogels composed of chitosan and sulfated polysaccharides of red microalgae

Gal Netanel Liberman, Ronit Bitton, Shoshana Arad-Malis

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Hydrogels can serve as antimicrobial wound-dressing materials: they act as a physical barrier to bacterial penetration and maintain a moist environment, with improved biocompatibility and mechanical properties. In this research, hydrogels were developed using sulfated polysaccharides from three red microalgae (sea, brackish or fresh water) combined with chitosan (PSsea/brackish/fresh-Chi hydrogels). We have chosen the PSsea-Chi hydrogels for further studies since they were the stiffest and stable under physiological conditions. Zinc was added to the hydrogels to increase antimicrobial activity. Rheological characterizations of Zn-PS-hydrogels indicated that the stiffness and swelling of the hydrogels decreased with increasing zinc concentration, resulting from the charge-screening effects. SEM analysis showed that Zn-PS-Chi hydrogels were highly porous and zinc-release measurements suggested that all hydrogels shared similar release profiles. Agar diffusion tests suggested that the Zn-PS-Chi hydrogels exhibited a broad-spectrum of antimicrobial activities. The presented characteristics of the Zn-PS-Chi hydrogels highlight their potential use as wound dressings.

Original languageEnglish
Article number123353
StatePublished - 12 Feb 2021


  • Antimicrobial wound dressings
  • Red microalgae sulfated polysaccharides
  • Zinc-chitosan-sulfated polysaccharides physical hydrogels

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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