Antimicrobial susceptibility patterns of enterococci causing infections in Europe

M. A. Schouten; A. Voss; J. A.A. Hoogkamp-Korstanje; C. Jebelean; H. Mittermayer; M. Rotter; M. J. Struelens; E. E. Keuleyan; A. Boras; J. Schindler; A. Bremmelgaard; J. Renneberg; N. Frimodt-Moeller; A. Lester; O. O. Liimatainen; J. Vuopio-Varkila; A. Andremont; C. Muller-Serleys; J. Etienne; J. Raymond; L. Bader; J. Heesemann; R. Luetticken; R. R. Reinert; G. Peters; R. Gross; P. M. Shah; G. Syrogiannopoulos; O. Vavatsi-Manou; A. Marton; E. Nagy; C. Block; P. Yagupsky; G. A. Botta; G. Marchiaro; S. Stefani; D. Gardovska; L. Drukalska; V. Usonis; H. P. Endtz; J. G.M. Koeleman; J. F.G.M. Meis; A. Sundsfjord; M. Basta; P. B. Heczko; E. Torbicka; J. Melo-Cristino; I. A. Popova; V. Krcmercy; M. Gubina; F. Asensi-Botet; C. Riestra; J. R. Cervilla; A. Trilla; J. Villa; L. G. Burman; M. H. Laurel; M. Rylander; R. Frei; G. Kanra; P. R. Chadwick; E. H. Price; H. Holzel

doi:10.1128/aac.43.10.2542

Antimicrobial susceptibility patterns of enterococci causing infections in Europe

M. A. Schouten, A. Voss, J. A.A. Hoogkamp-Korstanje, C. Jebelean, H. Mittermayer, M. Rotter, M. J. Struelens, E. E. Keuleyan, A. Boras, J. Schindler, A. Bremmelgaard, J. Renneberg, N. Frimodt-Moeller, A. Lester, O. O. Liimatainen, J. Vuopio-Varkila, A. Andremont, C. Muller-Serleys, J. Etienne, J. RaymondL. Bader, J. Heesemann, R. Luetticken, R. R. Reinert, G. Peters, R. Gross, P. M. Shah, G. Syrogiannopoulos, O. Vavatsi-Manou, A. Marton, E. Nagy, C. Block, P. Yagupsky, G. A. Botta, G. Marchiaro, S. Stefani, D. Gardovska, L. Drukalska, V. Usonis, H. P. Endtz, J. G.M. Koeleman, J. F.G.M. Meis, A. Sundsfjord, M. Basta, P. B. Heczko, E. Torbicka, J. Melo-Cristino, I. A. Popova, V. Krcmercy, M. Gubina, F. Asensi-Botet, C. Riestra, J. R. Cervilla, A. Trilla, J. Villa, L. G. Burman, M. H. Laurel, M. Rylander, R. Frei, G. Kanra, P. R. Chadwick, E. H. Price, H. Holzel

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Abstract

In vitro susceptibilities of 4,208 enterococci (83% Enterococcus faecalis isolates, 13.6% Enterococcus faecium isolates, and 3.4% isolates of other species) from patients in 27 European countries towards 16 antibiotics were determined. High-level resistance to gentamicin varied by country (range, 1 to 49%; mean, 22.6% ± 12.3%) and per species (19.7% E. faecalis isolates, 13.6% E. faecium isolates, 3.4% by other species). Vancomycin resistance was detected in 0.06% E. faecalis, 3.8% E. faecium, and 19.1% isolates of other species. All enterococci were susceptible to LY 333328 and everninomicin, and 25% of E. faecalis isolates and 85% of other enterococci were susceptible to quinupristin-dalfopristin. The MIC of moxifloxacin and trovafloxacin for ciprofloxacin-susceptible E. faecalis at which 90% of the isolates were inhibited was 0.25 to 0.5 μg/ml.

Original language	English
Pages (from-to)	2542-2546
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	43
Issue number	10
DOIs	https://doi.org/10.1128/aac.43.10.2542
State	Published - 1 Jan 1999

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Schouten, M. A., Voss, A., Hoogkamp-Korstanje, J. A. A., Jebelean, C., Mittermayer, H., Rotter, M., Struelens, M. J., Keuleyan, E. E., Boras, A., Schindler, J., Bremmelgaard, A., Renneberg, J., Frimodt-Moeller, N., Lester, A., Liimatainen, O. O., Vuopio-Varkila, J., Andremont, A., Muller-Serleys, C., Etienne, J., ... Holzel, H. (1999). Antimicrobial susceptibility patterns of enterococci causing infections in Europe. Antimicrobial Agents and Chemotherapy, 43(10), 2542-2546. https://doi.org/10.1128/aac.43.10.2542

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title = "Antimicrobial susceptibility patterns of enterococci causing infections in Europe",

abstract = "In vitro susceptibilities of 4,208 enterococci (83% Enterococcus faecalis isolates, 13.6% Enterococcus faecium isolates, and 3.4% isolates of other species) from patients in 27 European countries towards 16 antibiotics were determined. High-level resistance to gentamicin varied by country (range, 1 to 49%; mean, 22.6% ± 12.3%) and per species (19.7% E. faecalis isolates, 13.6% E. faecium isolates, 3.4% by other species). Vancomycin resistance was detected in 0.06% E. faecalis, 3.8% E. faecium, and 19.1% isolates of other species. All enterococci were susceptible to LY 333328 and everninomicin, and 25% of E. faecalis isolates and 85% of other enterococci were susceptible to quinupristin-dalfopristin. The MIC of moxifloxacin and trovafloxacin for ciprofloxacin-susceptible E. faecalis at which 90% of the isolates were inhibited was 0.25 to 0.5 μg/ml.",

author = "Schouten, {M. A.} and A. Voss and Hoogkamp-Korstanje, {J. A.A.} and C. Jebelean and H. Mittermayer and M. Rotter and Struelens, {M. J.} and Keuleyan, {E. E.} and A. Boras and J. Schindler and A. Bremmelgaard and J. Renneberg and N. Frimodt-Moeller and A. Lester and Liimatainen, {O. O.} and J. Vuopio-Varkila and A. Andremont and C. Muller-Serleys and J. Etienne and J. Raymond and L. Bader and J. Heesemann and R. Luetticken and Reinert, {R. R.} and G. Peters and R. Gross and Shah, {P. M.} and G. Syrogiannopoulos and O. Vavatsi-Manou and A. Marton and E. Nagy and C. Block and P. Yagupsky and Botta, {G. A.} and G. Marchiaro and S. Stefani and D. Gardovska and L. Drukalska and V. Usonis and Endtz, {H. P.} and Koeleman, {J. G.M.} and Meis, {J. F.G.M.} and A. Sundsfjord and M. Basta and Heczko, {P. B.} and E. Torbicka and J. Melo-Cristino and Popova, {I. A.} and V. Krcmercy and M. Gubina and F. Asensi-Botet and C. Riestra and Cervilla, {J. R.} and A. Trilla and J. Villa and Burman, {L. G.} and Laurel, {M. H.} and M. Rylander and R. Frei and G. Kanra and Chadwick, {P. R.} and Price, {E. H.} and H. Holzel",

year = "1999",

month = jan,

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doi = "10.1128/aac.43.10.2542",

language = "English",

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journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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Schouten, MA, Voss, A, Hoogkamp-Korstanje, JAA, Jebelean, C, Mittermayer, H, Rotter, M, Struelens, MJ, Keuleyan, EE, Boras, A, Schindler, J, Bremmelgaard, A, Renneberg, J, Frimodt-Moeller, N, Lester, A, Liimatainen, OO, Vuopio-Varkila, J, Andremont, A, Muller-Serleys, C, Etienne, J, Raymond, J, Bader, L, Heesemann, J, Luetticken, R, Reinert, RR, Peters, G, Gross, R, Shah, PM, Syrogiannopoulos, G, Vavatsi-Manou, O, Marton, A, Nagy, E, Block, C, Yagupsky, P, Botta, GA, Marchiaro, G, Stefani, S, Gardovska, D, Drukalska, L, Usonis, V, Endtz, HP, Koeleman, JGM, Meis, JFGM, Sundsfjord, A, Basta, M, Heczko, PB, Torbicka, E, Melo-Cristino, J, Popova, IA, Krcmercy, V, Gubina, M, Asensi-Botet, F, Riestra, C, Cervilla, JR, Trilla, A, Villa, J, Burman, LG, Laurel, MH, Rylander, M, Frei, R, Kanra, G, Chadwick, PR, Price, EH & Holzel, H 1999, 'Antimicrobial susceptibility patterns of enterococci causing infections in Europe', Antimicrobial Agents and Chemotherapy, vol. 43, no. 10, pp. 2542-2546. https://doi.org/10.1128/aac.43.10.2542

TY - JOUR

T1 - Antimicrobial susceptibility patterns of enterococci causing infections in Europe

AU - Schouten, M. A.

AU - Voss, A.

AU - Hoogkamp-Korstanje, J. A.A.

AU - Jebelean, C.

AU - Mittermayer, H.

AU - Rotter, M.

AU - Struelens, M. J.

AU - Keuleyan, E. E.

AU - Boras, A.

AU - Schindler, J.

AU - Bremmelgaard, A.

AU - Renneberg, J.

AU - Frimodt-Moeller, N.

AU - Lester, A.

AU - Liimatainen, O. O.

AU - Vuopio-Varkila, J.

AU - Andremont, A.

AU - Muller-Serleys, C.

AU - Etienne, J.

AU - Raymond, J.

AU - Bader, L.

AU - Heesemann, J.

AU - Luetticken, R.

AU - Reinert, R. R.

AU - Peters, G.

AU - Gross, R.

AU - Shah, P. M.

AU - Syrogiannopoulos, G.

AU - Vavatsi-Manou, O.

AU - Marton, A.

AU - Nagy, E.

AU - Block, C.

AU - Yagupsky, P.

AU - Botta, G. A.

AU - Marchiaro, G.

AU - Stefani, S.

AU - Gardovska, D.

AU - Drukalska, L.

AU - Usonis, V.

AU - Endtz, H. P.

AU - Koeleman, J. G.M.

AU - Meis, J. F.G.M.

AU - Sundsfjord, A.

AU - Basta, M.

AU - Heczko, P. B.

AU - Torbicka, E.

AU - Melo-Cristino, J.

AU - Popova, I. A.

AU - Krcmercy, V.

AU - Gubina, M.

AU - Asensi-Botet, F.

AU - Riestra, C.

AU - Cervilla, J. R.

AU - Trilla, A.

AU - Villa, J.

AU - Burman, L. G.

AU - Laurel, M. H.

AU - Rylander, M.

AU - Frei, R.

AU - Kanra, G.

AU - Chadwick, P. R.

AU - Price, E. H.

AU - Holzel, H.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - In vitro susceptibilities of 4,208 enterococci (83% Enterococcus faecalis isolates, 13.6% Enterococcus faecium isolates, and 3.4% isolates of other species) from patients in 27 European countries towards 16 antibiotics were determined. High-level resistance to gentamicin varied by country (range, 1 to 49%; mean, 22.6% ± 12.3%) and per species (19.7% E. faecalis isolates, 13.6% E. faecium isolates, 3.4% by other species). Vancomycin resistance was detected in 0.06% E. faecalis, 3.8% E. faecium, and 19.1% isolates of other species. All enterococci were susceptible to LY 333328 and everninomicin, and 25% of E. faecalis isolates and 85% of other enterococci were susceptible to quinupristin-dalfopristin. The MIC of moxifloxacin and trovafloxacin for ciprofloxacin-susceptible E. faecalis at which 90% of the isolates were inhibited was 0.25 to 0.5 μg/ml.

AB - In vitro susceptibilities of 4,208 enterococci (83% Enterococcus faecalis isolates, 13.6% Enterococcus faecium isolates, and 3.4% isolates of other species) from patients in 27 European countries towards 16 antibiotics were determined. High-level resistance to gentamicin varied by country (range, 1 to 49%; mean, 22.6% ± 12.3%) and per species (19.7% E. faecalis isolates, 13.6% E. faecium isolates, 3.4% by other species). Vancomycin resistance was detected in 0.06% E. faecalis, 3.8% E. faecium, and 19.1% isolates of other species. All enterococci were susceptible to LY 333328 and everninomicin, and 25% of E. faecalis isolates and 85% of other enterococci were susceptible to quinupristin-dalfopristin. The MIC of moxifloxacin and trovafloxacin for ciprofloxacin-susceptible E. faecalis at which 90% of the isolates were inhibited was 0.25 to 0.5 μg/ml.

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U2 - 10.1128/aac.43.10.2542

DO - 10.1128/aac.43.10.2542

M3 - Article

AN - SCOPUS:0032871309

SN - 0066-4804

VL - 43

SP - 2542

EP - 2546

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 10

ER -

Antimicrobial susceptibility patterns of enterococci causing infections in Europe

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