Antinuclear Autoantibodies in Sera of Healthy Pregnant Women and Their Offspring

BENJAMIN PIURA, ERNEST TAUBER, BATIA SAROV, LECHAIM NAGGAN, YEHUDA SHOENFELD

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

ABSTRACT: The presence of autoantibodies in the fetus has previously been investigated in the offspring of mothers with autoimmune diseases, but not in the offspring of healthy pregnant women. Employing the ELISA method, we examine four SLE‐associated autoantibodies (anti‐dsDNA, anti‐ssDNA, anti‐poly(I), and anti‐cardiolipin) in sera obtained from 196 healthy pregnant women and their offspring. All detected autoantibodies in maternal and blood cord sera were of the IgM isotype. Thirty‐four maternal sera (17.3%) were positive for one or more tested autoantibodies: 16 (8.1%) for one autoantibody alone, 17 (8.6%) for two autoantibodies, and one (0.5%) for three autoantibodies; 1.5%, 5.6%, 9.6%, and 10.2% of the maternal sera were positive for autoantibodies against dsDNA, ssDNA, poly(I), and cardiolipin, respectively. In only one blood cord serum sample was an autoantibody (IgM anti‐ssDNA) detected. This infant was born to a healthy seronegative mother. The finding that all offspring of IgM seropositive mothers are IgM seronegative is not surprising since maternal IgM autoantibodies do not cross the placenta. The finding of an IgM seropositive infant born to an IgM seronegative mother may indicate that the fetus is capable of self‐production of autoantibodies. 1988 Munksgaard

Original languageEnglish
Pages (from-to)116-119
Number of pages4
JournalAmerican Journal of Reproductive Immunology and Microbiology
Volume18
Issue number4
DOIs
StatePublished - 1 Jan 1988

Keywords

  • Autoantibodies
  • anti‐DNA antibodies
  • autoimmunity

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