TY - JOUR
T1 - Antioxidants and human diseases
AU - Rajendran, Peramaiyan
AU - Nandakumar, Natarajan
AU - Rengarajan, Thamaraiselvan
AU - Palaniswami, Rajendran
AU - Gnanadhas, Edwinoliver Nesamony
AU - Lakshminarasaiah, Uppalapati
AU - Gopas, Jacob
AU - Nishigaki, Ikuo
PY - 2014/9/25
Y1 - 2014/9/25
N2 - Oxidative stress plays a pivotal role in the development of human diseases. Reactive oxygen species (ROS) that includes hydrogen peroxide, hyphochlorus acid, superoxide anion, singlet oxygen, lipid peroxides, hypochlorite and hydroxyl radical are involved in growth, differentiation, progression and death of the cell. They can react with membrane lipids, nucleic acids, proteins, enzymes and other small molecules. Low concentrations of ROS has an indispensable role in intracellular signalling and defence against pathogens, while, higher amounts of ROS play a role in number of human diseases, including arthritis, cancer, diabetes, atherosclerosis, ischemia, failures in immunity and endocrine functions. Antioxidants presumably act as safeguard against the accumulation of ROS and their elimination from the system. The aim of this review is to highlight advances in understanding of the ROS and also to summarize the detailed impact and involvement of antioxidants in selected human diseases.
AB - Oxidative stress plays a pivotal role in the development of human diseases. Reactive oxygen species (ROS) that includes hydrogen peroxide, hyphochlorus acid, superoxide anion, singlet oxygen, lipid peroxides, hypochlorite and hydroxyl radical are involved in growth, differentiation, progression and death of the cell. They can react with membrane lipids, nucleic acids, proteins, enzymes and other small molecules. Low concentrations of ROS has an indispensable role in intracellular signalling and defence against pathogens, while, higher amounts of ROS play a role in number of human diseases, including arthritis, cancer, diabetes, atherosclerosis, ischemia, failures in immunity and endocrine functions. Antioxidants presumably act as safeguard against the accumulation of ROS and their elimination from the system. The aim of this review is to highlight advances in understanding of the ROS and also to summarize the detailed impact and involvement of antioxidants in selected human diseases.
KW - Antioxidant
KW - Cancer
KW - Diabetes
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84904052451&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2014.06.004
DO - 10.1016/j.cca.2014.06.004
M3 - Review article
C2 - 24933428
AN - SCOPUS:84904052451
SN - 0009-8981
VL - 436
SP - 332
EP - 347
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -