Antiviral activity of ethanol extracts of Ficus binjamina and Lilium candidum in vitro

Ludmila Yarmolinsky, Michele Zaccai, Shimon Ben-Shabat, David Mills, Mahmoud Huleihel

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


The antiviral activity of plant ethanol extracts against Herpes Simplex Virus-1 and -2 (HSV-1 and HSV-2) and Varicella-Zoster Virus (VZV) was investigated in vitro. Ficus binjamina, resistant to plant viruses, and Lilium candidum, which has a high susceptibility to plant viruses were used. Leaf extracts of F. binjamina inhibited all studied viruses, while its fruit extracts inhibited only VZV. L. candidum leaf extracts had no effect on VZV but strongly inhibited HSV-1 and slightly HSV-2. None of the extracts showed significant cytotoxic effect on uninfected Vero cells even at a concentration of 250μg/ml (CC 50>400μg/ml). The greatest antiviral effect was obtained when extracts were added to cells at the time of infection, whereas a partial inhibitory effect was observed when they were added post-infection. There was indirect evidence for strong interactions between the plant extracts and the viruses and weak interactions with the cell surface.

Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalNew Biotechnology
Issue number6
StatePublished - 31 Dec 2009

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Molecular Biology


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