Antiviral activity of ethanol extracts of Ficus binjamina and Lilium candidum in vitro

Ludmila Yarmolinsky; Michele Zaccai; Shimon Ben-Shabat; David Mills; Mahmoud Huleihel

doi:10.1016/j.nbt.2009.08.005

Antiviral activity of ethanol extracts of Ficus binjamina and Lilium candidum in vitro

Ludmila Yarmolinsky, Michele Zaccai, Shimon Ben-Shabat, David Mills, Mahmoud Huleihel

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The antiviral activity of plant ethanol extracts against Herpes Simplex Virus-1 and -2 (HSV-1 and HSV-2) and Varicella-Zoster Virus (VZV) was investigated in vitro. Ficus binjamina, resistant to plant viruses, and Lilium candidum, which has a high susceptibility to plant viruses were used. Leaf extracts of F. binjamina inhibited all studied viruses, while its fruit extracts inhibited only VZV. L. candidum leaf extracts had no effect on VZV but strongly inhibited HSV-1 and slightly HSV-2. None of the extracts showed significant cytotoxic effect on uninfected Vero cells even at a concentration of 250μg/ml (CC ₅₀>400μg/ml). The greatest antiviral effect was obtained when extracts were added to cells at the time of infection, whereas a partial inhibitory effect was observed when they were added post-infection. There was indirect evidence for strong interactions between the plant extracts and the viruses and weak interactions with the cell surface.

Original language	English
Pages (from-to)	307-313
Number of pages	7
Journal	New Biotechnology
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/j.nbt.2009.08.005
State	Published - 31 Dec 2009

ASJC Scopus subject areas

Biotechnology
Bioengineering
Molecular Biology

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title = "Antiviral activity of ethanol extracts of Ficus binjamina and Lilium candidum in vitro",

abstract = "The antiviral activity of plant ethanol extracts against Herpes Simplex Virus-1 and -2 (HSV-1 and HSV-2) and Varicella-Zoster Virus (VZV) was investigated in vitro. Ficus binjamina, resistant to plant viruses, and Lilium candidum, which has a high susceptibility to plant viruses were used. Leaf extracts of F. binjamina inhibited all studied viruses, while its fruit extracts inhibited only VZV. L. candidum leaf extracts had no effect on VZV but strongly inhibited HSV-1 and slightly HSV-2. None of the extracts showed significant cytotoxic effect on uninfected Vero cells even at a concentration of 250μg/ml (CC 50>400μg/ml). The greatest antiviral effect was obtained when extracts were added to cells at the time of infection, whereas a partial inhibitory effect was observed when they were added post-infection. There was indirect evidence for strong interactions between the plant extracts and the viruses and weak interactions with the cell surface.",

author = "Ludmila Yarmolinsky and Michele Zaccai and Shimon Ben-Shabat and David Mills and Mahmoud Huleihel",

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T1 - Antiviral activity of ethanol extracts of Ficus binjamina and Lilium candidum in vitro

AU - Yarmolinsky, Ludmila

AU - Zaccai, Michele

AU - Ben-Shabat, Shimon

AU - Mills, David

AU - Huleihel, Mahmoud

PY - 2009/12/31

Y1 - 2009/12/31

N2 - The antiviral activity of plant ethanol extracts against Herpes Simplex Virus-1 and -2 (HSV-1 and HSV-2) and Varicella-Zoster Virus (VZV) was investigated in vitro. Ficus binjamina, resistant to plant viruses, and Lilium candidum, which has a high susceptibility to plant viruses were used. Leaf extracts of F. binjamina inhibited all studied viruses, while its fruit extracts inhibited only VZV. L. candidum leaf extracts had no effect on VZV but strongly inhibited HSV-1 and slightly HSV-2. None of the extracts showed significant cytotoxic effect on uninfected Vero cells even at a concentration of 250μg/ml (CC 50>400μg/ml). The greatest antiviral effect was obtained when extracts were added to cells at the time of infection, whereas a partial inhibitory effect was observed when they were added post-infection. There was indirect evidence for strong interactions between the plant extracts and the viruses and weak interactions with the cell surface.

AB - The antiviral activity of plant ethanol extracts against Herpes Simplex Virus-1 and -2 (HSV-1 and HSV-2) and Varicella-Zoster Virus (VZV) was investigated in vitro. Ficus binjamina, resistant to plant viruses, and Lilium candidum, which has a high susceptibility to plant viruses were used. Leaf extracts of F. binjamina inhibited all studied viruses, while its fruit extracts inhibited only VZV. L. candidum leaf extracts had no effect on VZV but strongly inhibited HSV-1 and slightly HSV-2. None of the extracts showed significant cytotoxic effect on uninfected Vero cells even at a concentration of 250μg/ml (CC 50>400μg/ml). The greatest antiviral effect was obtained when extracts were added to cells at the time of infection, whereas a partial inhibitory effect was observed when they were added post-infection. There was indirect evidence for strong interactions between the plant extracts and the viruses and weak interactions with the cell surface.

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Antiviral activity of ethanol extracts of Ficus binjamina and Lilium candidum in vitro

Abstract

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