Apoptosis of Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma revisited

Daniel Benharroch, Inbal Einav, Alexandra Feldman, Amalia Levy, Samuel Ariad, Jacob Gopas

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


We scrutinized the role of apoptosis of the Hodgkin-Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) and critically reviewed its features in the light of conflicting evidence. In this study, we found that tumor cells in this neoplasm showed inhibition of apoptosis in 55% of the 217 cHL cases only. It is also suggested that the two factors considered responsible for apoptosis inhibition in HRS cells, nuclear factor-κB and the latent membrane protein-1 of the Epstein-Barr virus, do not correlate with apoptosis inhibition, in contrast with the findings in the consensual pathogenetic scheme. The most significant association of HRS cell apoptosis was with p53, the negative expression of which related with a high apoptotic index (p = 0.001). These findings support our contention that the role of apoptosis in the HRS cells of Hodgkin lymphoma has not been completely elucidated and is at variance with that in the consensus.

Original languageEnglish
Pages (from-to)339-345
Number of pages7
Issue number5
StatePublished - 1 May 2010


  • Apoptotic index
  • Hodgkin lymphoma
  • Measles virus
  • NF-κB

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)


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