TY - JOUR
T1 - Apoptosis of Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma revisited
AU - Benharroch, Daniel
AU - Einav, Inbal
AU - Feldman, Alexandra
AU - Levy, Amalia
AU - Ariad, Samuel
AU - Gopas, Jacob
PY - 2010/5/1
Y1 - 2010/5/1
N2 - We scrutinized the role of apoptosis of the Hodgkin-Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) and critically reviewed its features in the light of conflicting evidence. In this study, we found that tumor cells in this neoplasm showed inhibition of apoptosis in 55% of the 217 cHL cases only. It is also suggested that the two factors considered responsible for apoptosis inhibition in HRS cells, nuclear factor-κB and the latent membrane protein-1 of the Epstein-Barr virus, do not correlate with apoptosis inhibition, in contrast with the findings in the consensual pathogenetic scheme. The most significant association of HRS cell apoptosis was with p53, the negative expression of which related with a high apoptotic index (p = 0.001). These findings support our contention that the role of apoptosis in the HRS cells of Hodgkin lymphoma has not been completely elucidated and is at variance with that in the consensus.
AB - We scrutinized the role of apoptosis of the Hodgkin-Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) and critically reviewed its features in the light of conflicting evidence. In this study, we found that tumor cells in this neoplasm showed inhibition of apoptosis in 55% of the 217 cHL cases only. It is also suggested that the two factors considered responsible for apoptosis inhibition in HRS cells, nuclear factor-κB and the latent membrane protein-1 of the Epstein-Barr virus, do not correlate with apoptosis inhibition, in contrast with the findings in the consensual pathogenetic scheme. The most significant association of HRS cell apoptosis was with p53, the negative expression of which related with a high apoptotic index (p = 0.001). These findings support our contention that the role of apoptosis in the HRS cells of Hodgkin lymphoma has not been completely elucidated and is at variance with that in the consensus.
KW - Apoptotic index
KW - Hodgkin lymphoma
KW - Measles virus
KW - NF-κB
UR - http://www.scopus.com/inward/record.url?scp=77951109292&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0463.2010.02600.x
DO - 10.1111/j.1600-0463.2010.02600.x
M3 - Article
AN - SCOPUS:77951109292
SN - 1600-0463
VL - 118
SP - 339
EP - 345
JO - APMIS Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - APMIS Acta Pathologica, Microbiologica et Immunologica Scandinavica
IS - 5
ER -
