Appearance of guillain-barré syndrome in patients during corticosteroid treatment

Israel Steiner, Itzhak Wirguin, Oded Abramsky

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Three patients developed acute Guillain-Barré syndrome while on steroid treatment. The first patient suffered from ulcerative colitis and developed Guillain-Barré syndrome when the steroid dosage was being tapered. Another patient with long-standing multiple sclerosis received steroids during relapse and the Guillain-Barré syndrome appeared while treatment was reduced. The third patient, with aqueductal stenosis and ventriculoatrial shunt, who received steroids when malfunction of the shunt was suspected, developed Guillain-Barré syndrome while steroids were being tapered. Based on the putative immune pathogenesis of inflammatory demyelinating polyneuropathy, the occurrence of the syndrome in these patients could have been due to a selective effect of low-dose steroids on a specific, maybe suppressor lymphocyte subpopulation.

Original languageEnglish
Pages (from-to)221-223
Number of pages3
JournalJournal of Neurology
Issue number4
StatePublished - 1 Aug 1986
Externally publishedYes


  • Corticosteroid
  • Guillain-Barré syndrome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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