Application of G-proteins in the molecular diagnosis of psychiatric disorders

Gabriel Schreiber, Sofia Avissar

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Mental disorders are highly prevalent and often difficult to diagnose. Although significant advances have been achieved in medication for mental disorders, the diagnosis and treatment monitoring of these disorders remain in a static situation. The absence of objective diagnostic 'gold standards', derives from the special complexity of diagnosis in psychiatry. Heterotrimeric G-proteins are crucial elements in post-receptor information transduction. These proteins have been implicated in the biochemical mechanism of action of drugs used to treat psychiatric disorders. G-protein measurements have unravelled a differential pattern characteristic of each of the major mental disorders. The accumulated data supports the potential use of G-protein measures as state-dependent markers for the biochemical diagnosis of mental disorders and as aid in the biochemical monitoring of the response to a specific treatment.

Original languageEnglish
Pages (from-to)69-80
Number of pages12
JournalExpert Review of Molecular Diagnostics
Volume3
Issue number1
DOIs
StatePublished - 1 Jan 2003

Keywords

  • Diagnostic market
  • G-protein
  • Mononuclear leukocytes
  • Mood disorders
  • Psychiatry
  • Schizophrenia

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