TY - JOUR
T1 - Application of nanomaterials as potential quorum quenchers for disease
T2 - Recent advances and challenges
AU - Alghamdi, Saad
AU - Khandelwal, Krisha
AU - Pandit, Soumya
AU - Roy, Arpita
AU - Ray, Subhasree
AU - Alsaiari, Ahad Amer
AU - Aljuaid, Abdulelah
AU - Almehmadi, Mazen
AU - Allahyani, Mamdouh
AU - Sharma, Rohit
AU - Anand, Jigisha
AU - Alshareef, Ahmad Adnan
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Chemical signal molecules are used by bacteria to interact with one another. Small hormone-like molecules known as autoinducers are produced, released, detected, and responded to during chemical communication. Quorum Sensing (QS) is the word for this procedure; it allows bacterial populations to communicate and coordinate group behavior. Several research has been conducted on using inhibitors to prevent QS and minimize the detrimental consequences. Through the enzymatic breakdown of the autoinducer component, by preventing the formation of autoinducers, or by blocking their reception by adding some compounds (inhibitors) that can mimic the autoinducers, a technique known as “quorum quenching” (QQ) disrupts microbial communication. Numerous techniques, including colorimetry, electrochemistry, bioluminescence, chemiluminescence, fluorescence, chromatography-mass spectroscopy, and many more, can be used to test QS/QQ. They all permit quantitative and qualitative measurements of QS/QQ molecules. The mechanism of QS and QQ, as well as the use of QQ in the prevention of biofilms, are all elaborated upon in this writing, along with the fundamental study of nanoparticle (NP)in QQ. Q.
AB - Chemical signal molecules are used by bacteria to interact with one another. Small hormone-like molecules known as autoinducers are produced, released, detected, and responded to during chemical communication. Quorum Sensing (QS) is the word for this procedure; it allows bacterial populations to communicate and coordinate group behavior. Several research has been conducted on using inhibitors to prevent QS and minimize the detrimental consequences. Through the enzymatic breakdown of the autoinducer component, by preventing the formation of autoinducers, or by blocking their reception by adding some compounds (inhibitors) that can mimic the autoinducers, a technique known as “quorum quenching” (QQ) disrupts microbial communication. Numerous techniques, including colorimetry, electrochemistry, bioluminescence, chemiluminescence, fluorescence, chromatography-mass spectroscopy, and many more, can be used to test QS/QQ. They all permit quantitative and qualitative measurements of QS/QQ molecules. The mechanism of QS and QQ, as well as the use of QQ in the prevention of biofilms, are all elaborated upon in this writing, along with the fundamental study of nanoparticle (NP)in QQ. Q.
KW - Antimicrobial
KW - Biofilm
KW - Nanoparticles
KW - Quorum quenching
KW - Quorum sensing
UR - http://www.scopus.com/inward/record.url?scp=85173050677&partnerID=8YFLogxK
U2 - 10.1016/j.pbiomolbio.2023.08.005
DO - 10.1016/j.pbiomolbio.2023.08.005
M3 - Article
C2 - 37666284
AN - SCOPUS:85173050677
SN - 0079-6107
VL - 184
SP - 13
EP - 31
JO - Progress in Biophysics and Molecular Biology
JF - Progress in Biophysics and Molecular Biology
ER -