Application of Photofrin II as a specific radiosensitising agent in patients with bladder cancer—a report of two cases

M. Schaffer, P. M. Schaffer, M. Vogesser, B. Ertl-Wagner, J. Rauch, R. Oberneder, G. Jori, A. Hofstetter, E. Dühmke

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background: the effect of ionizing radiation on tumour tissues can be optimised by adding radiosensitising agents to enhance tumour inactivation. Photofrin II has been approved as a photosensitising agent for the photodynamic therapy (PDT) of selected solid tumours. At present, no chemical modifier has been found to act as a selective radiosensitiser. We report here the first use of Photofrin II as a radiosensitising agent to enhance radiation therapy. Patients: two patients, one female with unresectable bladder cancer and one male with recurrent inoperable bladder cancer, were treated with radiation therapy (44.8 Gy + 14 Gy boost) of the pelvic region. 24 hours before initiation of therapy the patients were intravenously injected with 1 mg kg−1 Photofrin II (Axcan, Canada). Results: magnetic resonance imaging of the pelvis with a standardized protocol demonstrated a reduction in tumour volume of approximately 40% in the female patient and 35% in the male patient. The female patient was operated upon after conclusion of radiotherapy, the male patient refused the operation. No severe side effects were observed. Conclusion: Photofrin II is a promising radiosensitising agent in the treatment of patients with advanced solid tumours.

Original languageEnglish
Pages (from-to)686-689
Number of pages4
JournalPhotochemical and Photobiological Sciences
Issue number9
StatePublished - 11 Sep 2002
Externally publishedYes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry


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