Application of underdamped Langevin dynamics simulations for the study of diffusion from a drug-eluting stent

Shaked Regev, Oded Farago

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We use a one-dimensional two layer model with a semi-permeable membrane to study the diffusion of a therapeutic drug delivered from a drug-eluting stent (DES). The rate of drug transfer from the stent coating to the arterial wall is calculated by using underdamped Langevin dynamics simulations. Our results reveal that the membrane has virtually no delay effect on the rate of delivery from the DES. The work demonstrates the great potential of underdamped Langevin dynamics simulations as an easy to implement, efficient, method for solving complicated diffusion problems in systems with a spatially-dependent diffusion coefficient.

Original languageEnglish
Pages (from-to)231-239
Number of pages9
JournalPhysica A: Statistical Mechanics and its Applications
Volume507
DOIs
StatePublished - 1 Oct 2018

Keywords

  • Drug eluting stent
  • Heterogeneous diffusion
  • Langevin dynamics simulations
  • Layered systems
  • Semi-permeable membrane

ASJC Scopus subject areas

  • Statistics and Probability
  • Condensed Matter Physics

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