Abstract
Obtaining an understanding of the mechanism underlying the interrelations between the structure and function of HIV-1 is of pivotal importance. In previous decades, this mechanism was addressed extensively in a variety of studies using conventional approaches. More recently, atomic force microscopy, which is a relatively new technique with unique capabilities, has been utilized to study HIV-1 biology. Atomic force microscopy can generate high-resolution images at the nanome-ter-scale and analyze the mechanical properties of individual HIV-1 virions, virus components (e.g., capsids), and infected live cells under near-physiological environments. This review describes the working principles and various imaging and analysis modes of atomic force microscopy, and elab-orates on its distinctive contributions to HIV-1 research in areas such as mechanobiology and the physics of infection.
Original language | English |
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Article number | 648 |
Journal | Viruses |
Volume | 14 |
Issue number | 3 |
DOIs | |
State | Published - 1 Mar 2022 |
Keywords
- HIV-1
- atomic force microscopy
- imaging
- mechanical properties
ASJC Scopus subject areas
- Infectious Diseases
- Virology