Approaches and technologies in male fertility preservation

Mahmoud Huleihel, Eitan Lunenfeld

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Male fertility preservation is required when treatment with an aggressive chemo-/-radiotherapy, which may lead to irreversible sterility. Due to new and efficient protocols of cancer treatments, surviving rates are more than 80%. Thus, these patients are looking forward to family life and fathering their own biological children after treatments. Whereas adult men can cryopreserve their sperm for future use in assistance reproductive technologies (ART), this is not an option in prepubertal boys who cannot produce sperm at this age. In this review, we summarize the different technologies for male fertility preservation with emphasize on prepubertal, which have already been examined and/or demonstrated in vivo and/or in vitro using animal models and, in some cases, using human tissues. We discuss the limitation of these technologies for use in human fertility preservation. This update review can assist physicians and patients who are scheduled for aggressive chemo-/radiotherapy, specifically prepubertal males and their parents who need to know about the risks of the treatment on their future fertility and the possible present option of fertility preservation.

Original languageEnglish
Article number5471
Pages (from-to)1-19
Number of pages19
JournalInternational Journal of Molecular Sciences
Issue number15
StatePublished - 1 Aug 2020


  • Cancer and male infertility
  • Chemotherapy
  • Cytokines and male infertility
  • In vitro culture of spermatogonial cells
  • Male fertility preservation
  • Male infertility
  • Organ culture
  • Spermatogenesis
  • Testis
  • Three-dimension in vitro culture system

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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