Aptamer-functionalized nanoparticles for targeted cancer therapy

Ananya Kar, Smruti Rekha Rout, Lopamudra Giri, Amirhossein Sahebkar, Prashant Kesharwani, Rambabu Dandela

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

Aptamers are a novel type of single-stranded RNA/DNA molecule that is chosen by a screening mechanism among synthetic nucleic acid collections by a process called systematic evolution of ligands by exponential enrichment. Aptamer-functionalized technologies had frequently been used and shown promising achievements in a variety of disciplines because of their particular high binding affinity, ease of modification, minimal immunogenicity, and targeting ability. But they get a long journey to go before they can be marketed, and a handful of aptamer-functionalized systems have to come into picture to achieve industrial and clinicato enable scientists to enhance or build unique and superior aptamer-functionalized technologies, it's logies, it's indeed vital to investigate the latest research advancements in aptamer-functionalized technologies. Throughout this section of the book, we initially discuss the preparation of various aptamer-functionalized nanomaterials, as well as significant improvements in aptamer-functionalized frameworks' utilizations in biosensing to detect cancerous cells, targeted drug delivery and cancer therapy, targeted photodynamic therapy, thermo-chemotherapy, and other applications besides cancer therapy, along with theorizing on their prospects.

Original languageEnglish
Title of host publicationAptamers Engineered Nanocarriers for Cancer Therapy
PublisherElsevier
Pages191-218
Number of pages28
ISBN (Electronic)9780323858816
ISBN (Print)9780323900768
DOIs
StatePublished - 1 Jan 2022
Externally publishedYes

Keywords

  • Aptamer
  • Aptamer-functionalized systems
  • Biosensing
  • Chemotherapy
  • Targeted drug delivery

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology

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