TY - JOUR
T1 - Aptamer-guided Selective Delivery of Therapeutics to Breast Cancer Cells Expressing Specific Biomarkers
AU - Pandey, Swaroop Kumar
AU - Parul, Mradula
AU - Santhanam, Manikandan
N1 - Publisher Copyright:
© 2024 Bentham Science Publishers.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Cancer biomarkers or tumor-associated antigens (TAA) are the focus area of current research in cancer biology for diagnosis, prognosis, screening, and targeted treatments. Breast cancer is the second most common type of cancer, affecting women more than men. Conventional methods and antibody-targeted therapies are less effective and suffer systemic cytotoxicity, poor tissue sensitivity, low penetration capacity, and reduced accumulation of the drug in tumor cells that limit its application and sometimes result in treatment failure. Opting for aptamer-mediated targeted delivery of various anti-cancer agents (drugs, siRNA, miRNA, shRNA and peptides) could possibly overcome these limitations by utilizing aptamer as a targeting ligand. The purpose of this article is to review the novel indicative biomarkers of breast cancer and also describe current applications of aptamer-guided active targeting systems in breast cancer therapy in vivo and in vitro.
AB - Cancer biomarkers or tumor-associated antigens (TAA) are the focus area of current research in cancer biology for diagnosis, prognosis, screening, and targeted treatments. Breast cancer is the second most common type of cancer, affecting women more than men. Conventional methods and antibody-targeted therapies are less effective and suffer systemic cytotoxicity, poor tissue sensitivity, low penetration capacity, and reduced accumulation of the drug in tumor cells that limit its application and sometimes result in treatment failure. Opting for aptamer-mediated targeted delivery of various anti-cancer agents (drugs, siRNA, miRNA, shRNA and peptides) could possibly overcome these limitations by utilizing aptamer as a targeting ligand. The purpose of this article is to review the novel indicative biomarkers of breast cancer and also describe current applications of aptamer-guided active targeting systems in breast cancer therapy in vivo and in vitro.
KW - Breast cancer
KW - aptamers
KW - biomarkers
KW - drugs
KW - nanocarriers
KW - therapeutics
UR - http://www.scopus.com/inward/record.url?scp=85197523727&partnerID=8YFLogxK
U2 - 10.2174/1573394719666230911113126
DO - 10.2174/1573394719666230911113126
M3 - Review article
AN - SCOPUS:85197523727
SN - 1573-3947
VL - 20
SP - 434
EP - 460
JO - Current Cancer Therapy Reviews
JF - Current Cancer Therapy Reviews
IS - 5
ER -