Are Haemophilus influenzae infections a significant problem in India? A prospective study and review

Invasive Bacterial Infections Surveillance (IBIS) Group of the International Clinical Epidemiology Network

doi:10.1086/339327

Are Haemophilus influenzae infections a significant problem in India? A prospective study and review

Invasive Bacterial Infections Surveillance (IBIS) Group of the International Clinical Epidemiology Network

The International Center of Health Innovation & Nutrition in memory of Manya Igel

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

It has been suggested Haemophilus influenzae serotype b (Hib) disease is uncommon in Asia. During 1993-1997, we conducted prospective surveillance of acute infections caused by H. influenzae in 6 academic referral Indian hospitals. The study included 5798 patients aged 1 month to 50 years who had diseases likely to be caused by H. influenzae; 75% of the patients were aged <5 years. A total of 125 H. influenzae infections were detected, 97% of which were caused by Hib. Of 125 isolates, 108 (86%) were from children aged <5 years, and 11 (9%) were from adults aged >18 years. Sixty-two percent of the patients had meningitis. The case-fatality rate was 11% overall and 20% in infants with Hib meningitis. Up to 60% of all isolates were resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, or erythromycin; 32% were resistant to 3 antimicrobial drugs, but none were resistant to third-generation cephalosporins. These data suggest that available Hib vaccines will benefit Indian children.

Original language	English
Pages (from-to)	949-957
Number of pages	9
Journal	Clinical Infectious Diseases
Volume	34
Issue number	7
DOIs	https://doi.org/10.1086/339327
State	Published - 1 Apr 2002

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1086/339327

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@article{7594cd42a29b411980347d7223aab03b,

title = "Are Haemophilus influenzae infections a significant problem in India? A prospective study and review",

abstract = "It has been suggested Haemophilus influenzae serotype b (Hib) disease is uncommon in Asia. During 1993-1997, we conducted prospective surveillance of acute infections caused by H. influenzae in 6 academic referral Indian hospitals. The study included 5798 patients aged 1 month to 50 years who had diseases likely to be caused by H. influenzae; 75% of the patients were aged <5 years. A total of 125 H. influenzae infections were detected, 97% of which were caused by Hib. Of 125 isolates, 108 (86%) were from children aged <5 years, and 11 (9%) were from adults aged >18 years. Sixty-two percent of the patients had meningitis. The case-fatality rate was 11% overall and 20% in infants with Hib meningitis. Up to 60% of all isolates were resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, or erythromycin; 32% were resistant to 3 antimicrobial drugs, but none were resistant to third-generation cephalosporins. These data suggest that available Hib vaccines will benefit Indian children.",

author = "{Invasive Bacterial Infections Surveillance (IBIS) Group of the International Clinical Epidemiology Network} and K. Thomas and Lalitha, {M. K.} and Steinhoff, {Mark C.} and Arora, {N. K.} and A. Ratan and B. Das and Awasthi, {S. K.} and Mistra, {P. K.} and J. Amita and R. Daivanayagam and P. Manjula and D. Jain and V. Agarwal and P. Ravindran and T. Cherian and P. Raghupathy and P. Moses and Jesudason, {M. V.} and Brahmadathan, {K. N.} and L. Jayseelan and Jonh, {T. J.} and D. Fraser and S. Kessler and J. Farrar and S. Halstead and P. Charache and R. Arthur and A. Manoharan and S. Deorari and N. Arora and G. Selvakumar",

year = "2002",

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doi = "10.1086/339327",

language = "English",

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T1 - Are Haemophilus influenzae infections a significant problem in India? A prospective study and review

AU - Invasive Bacterial Infections Surveillance (IBIS) Group of the International Clinical Epidemiology Network

AU - Thomas, K.

AU - Lalitha, M. K.

AU - Steinhoff, Mark C.

AU - Arora, N. K.

AU - Ratan, A.

AU - Das, B.

AU - Awasthi, S. K.

AU - Mistra, P. K.

AU - Amita, J.

AU - Daivanayagam, R.

AU - Manjula, P.

AU - Jain, D.

AU - Agarwal, V.

AU - Ravindran, P.

AU - Cherian, T.

AU - Raghupathy, P.

AU - Moses, P.

AU - Jesudason, M. V.

AU - Brahmadathan, K. N.

AU - Jayseelan, L.

AU - Jonh, T. J.

AU - Fraser, D.

AU - Kessler, S.

AU - Farrar, J.

AU - Halstead, S.

AU - Charache, P.

AU - Arthur, R.

AU - Manoharan, A.

AU - Deorari, S.

AU - Arora, N.

AU - Selvakumar, G.

PY - 2002/4/1

Y1 - 2002/4/1

N2 - It has been suggested Haemophilus influenzae serotype b (Hib) disease is uncommon in Asia. During 1993-1997, we conducted prospective surveillance of acute infections caused by H. influenzae in 6 academic referral Indian hospitals. The study included 5798 patients aged 1 month to 50 years who had diseases likely to be caused by H. influenzae; 75% of the patients were aged <5 years. A total of 125 H. influenzae infections were detected, 97% of which were caused by Hib. Of 125 isolates, 108 (86%) were from children aged <5 years, and 11 (9%) were from adults aged >18 years. Sixty-two percent of the patients had meningitis. The case-fatality rate was 11% overall and 20% in infants with Hib meningitis. Up to 60% of all isolates were resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, or erythromycin; 32% were resistant to 3 antimicrobial drugs, but none were resistant to third-generation cephalosporins. These data suggest that available Hib vaccines will benefit Indian children.

AB - It has been suggested Haemophilus influenzae serotype b (Hib) disease is uncommon in Asia. During 1993-1997, we conducted prospective surveillance of acute infections caused by H. influenzae in 6 academic referral Indian hospitals. The study included 5798 patients aged 1 month to 50 years who had diseases likely to be caused by H. influenzae; 75% of the patients were aged <5 years. A total of 125 H. influenzae infections were detected, 97% of which were caused by Hib. Of 125 isolates, 108 (86%) were from children aged <5 years, and 11 (9%) were from adults aged >18 years. Sixty-two percent of the patients had meningitis. The case-fatality rate was 11% overall and 20% in infants with Hib meningitis. Up to 60% of all isolates were resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, or erythromycin; 32% were resistant to 3 antimicrobial drugs, but none were resistant to third-generation cephalosporins. These data suggest that available Hib vaccines will benefit Indian children.

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U2 - 10.1086/339327

DO - 10.1086/339327

M3 - Review article

C2 - 11880961

AN - SCOPUS:0036532024

SN - 1058-4838

VL - 34

SP - 949

EP - 957

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 7

ER -

Are Haemophilus influenzae infections a significant problem in India? A prospective study and review

Abstract

ASJC Scopus subject areas

UN SDGs

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