Are Higher Body Mass Index and Worse Metabolic Parameters Associated with More Aggressive Differentiated Thyroid Cancer? A Retrospective Cohort Study

Yasmin Abu Arar, Michael Shilo, Natalya Bilenko, Michael Friger, Hagit Marsha, David Fisher, Merav Fraenkel, Uri Yoel

Research output: Contribution to journalArticlepeer-review

Abstract

Obesity is a risk factor for differentiated thyroid cancer (DTC), but the association with DTC aggressiveness is controversial. To evaluate the association between preoperative body mass index (BMI)/other metabolic parameters and DTC aggressiveness in our surgical cohort, we retrospectively evaluated patients following thyroid surgery who were diagnosed with DTC between December 2013 and January 2021. Baseline characteristics, histopathological features, treatment modalities, and follow-up data were studied. We conducted logistic regression to analyze the association between BMI/other metabolic parameters and adverse DTC features. The final study cohort included 211 patients (79.6% women; mean age± standard deviation 48.7 ± 15.9 years): 66 (31.3%) with normal weight, 81 (38.4%) with overweight, and 64 (30.3%) with obesity. The median follow-up was 51 months (range 7–93). Complete versus partial thyroidectomy was more common among patients living with overweight or obesity than in normal weight patients (79.7% versus 61.7%, p = 0.017, respectively). Logistic regression demonstrated that higher BMI was associated with mildly increased risk for lymph nodes metastases (odds ratio [OR] 1.077, 95% CI: 1.013–1.145), and higher triglycerides/high-density lipoprotein–cholesterol (TG/HDL-C) ratio was associated with aggressive histological variants of DTC (OR 1.269, 95% CI 1.001–1.61). To conclude, specific adverse clinical and histopathological DTC features were indeed associated with higher BMI and higher TG/HDL-C ratio.

Original languageEnglish
Article number581
JournalHealthcare (Switzerland)
Volume12
Issue number5
DOIs
StatePublished - 1 Mar 2024

Keywords

  • PTC histological variants
  • body mass index (BMI)
  • differentiated thyroid cancer (DTC)
  • metabolic syndrome
  • obesity
  • papillary thyroid carcinoma (PTC)
  • triglycerides/high-density lipoprotein (HDL)–cholesterol ratio

ASJC Scopus subject areas

  • Health Information Management
  • Health Policy
  • Health Informatics
  • Leadership and Management

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