Are individual differences in fatigue vulnerability related to baseline differences in cortical activation?

John A. Caldwell, Jennifer K. Smith, J. Lynn Caldwell, David L. Brown, Qiwen Mu, Alexander Mishory, Gordon Peters, Mark S. George

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Recent evidence suggests that underlying patterns of cortical activation may partially account for individual differences in susceptibility to the effects of sleep deprivation. Here, functional magnetic resonance imaging (fMRI) was used to examine the activation of military pilots whose sleep-deprivation vulnerability previously was quantified. A Sternberg Working Memory Task (SWMT; S. Sternberg. 1966) was completed alternately with a control task during a 13-min blood oxygen level-dependent fMRI scan. Examination of the activated voxels in response to SWMT indicated that, as a group, the pilots were more similar to fatigue-resistant nonpilots than to fatigue-vulnerable nonpilots. Within the pilots, cortical activation was significantly related to fatigue vulnerability on simulator-flight performance. These preliminary data suggest that baseline fMRI scan activation during a working memory task may correlate with fatigue susceptibility.

Original languageEnglish
Pages (from-to)694-707
Number of pages14
JournalBehavioral Neuroscience
Volume119
Issue number3
DOIs
StatePublished - 1 Jun 2005
Externally publishedYes

Keywords

  • Aviation
  • Fatigue
  • Functional magnetic resonance imaging
  • Individual differences
  • Sleep deprivation

ASJC Scopus subject areas

  • Behavioral Neuroscience

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