Aromatic ring cleavage of 2-amino-4-tert-butylphenol by a nonheme iron(II) complex: Functional model of 2-aminophenol dioxygenases

Biswarup Chakraborty; Tapan Kanti Paine

doi:10.1002/anie.201206922

Aromatic ring cleavage of 2-amino-4-tert-butylphenol by a nonheme iron(II) complex: Functional model of 2-aminophenol dioxygenases

Biswarup Chakraborty, Tapan Kanti Paine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Biomimetic aromatic ring cleavage: An iron(II)-2-aminophenolate complex (see picture, right) with a tetradentate ligand reacts with dioxygen to cleave the aromatic C-C bond of 2-amino-4-tert-butylphenolate to form 4-tert-butyl-2-picolinate. This complex represents a functional model of 2-aminophenol-1,6-dioxygenase (APD) and 3-hydroxyanthranilate-3,4-dioxygenase (HAD).

Original language	English
Pages (from-to)	920-924
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	3
DOIs	https://doi.org/10.1002/anie.201206922
State	Published - 14 Jan 2013
Externally published	Yes

Keywords

biomimetic model
cleavage reactions
dioxygenases
enzyme models
iron

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201206922

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abstract = "Biomimetic aromatic ring cleavage: An iron(II)-2-aminophenolate complex (see picture, right) with a tetradentate ligand reacts with dioxygen to cleave the aromatic C-C bond of 2-amino-4-tert-butylphenolate to form 4-tert-butyl-2-picolinate. This complex represents a functional model of 2-aminophenol-1,6-dioxygenase (APD) and 3-hydroxyanthranilate-3,4-dioxygenase (HAD).",

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AU - Paine, Tapan Kanti

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Y1 - 2013/1/14

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AB - Biomimetic aromatic ring cleavage: An iron(II)-2-aminophenolate complex (see picture, right) with a tetradentate ligand reacts with dioxygen to cleave the aromatic C-C bond of 2-amino-4-tert-butylphenolate to form 4-tert-butyl-2-picolinate. This complex represents a functional model of 2-aminophenol-1,6-dioxygenase (APD) and 3-hydroxyanthranilate-3,4-dioxygenase (HAD).

KW - biomimetic model

KW - cleavage reactions

KW - dioxygenases

KW - enzyme models

KW - iron

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Aromatic ring cleavage of 2-amino-4-tert-butylphenol by a nonheme iron(II) complex: Functional model of 2-aminophenol dioxygenases

Abstract

Keywords

ASJC Scopus subject areas

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