Aspirin desensitization for ASA triad patients - A prospective study of the rhinologist's perspective

B. Forer, S. Kivity, J. Sade, R. Landsberg

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Objectives/Problem: To determine the sinonasal effect of aspirin salicylic acid (ASA) desensitization in patients with nasal polyps, asthma and aspirin intolerance (ASA triad). Methods of study: Patients with ASA triad were recruited from the outpatient otolaryngology clinic. They underwent a program of ASA desensitization (2005-2008) with prospective assessment of subjective and objective responses. Incremental doses of aspirin were given to reach a target of 625 mg twice daily during a period of 3-5 days. A maintenance dose was then given for the study period. The patients also received inhaled and topical nasal steroids, antihistamines and beta agonists for asthma control, but no systemic steroid treatment. Main results: Of the original 27 enrolled subjects, 10 elected to discontinue treatment and five dropped out because of treatment complications. The objective evaluation of the polypoid sinonasal disease in the remaining 12 patients (4 males, 8 females, age range 22-63 years) revealed only mild improvement. In contrast, the patients' subjective feeling of nasal congestion, nasal discharge and overall discomfort improved significantly. Conclusions: Aspirin desensitization has a favorable subjective effect on certain nasal symptoms among ASA triad patients, but the objective effect on polypoid mass is not significant.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalRhinology
Volume49
Issue number1
DOIs
StatePublished - 4 Apr 2011

Keywords

  • ASA triad
  • Aspirin
  • Asthma
  • Desensitization
  • Polyposis
  • Prospective study

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