Aspirin, warfarin and a thienopyridine for acute coronary syndromes

Yuval Konstantino; Zaza Iakobishvili; Avital Porter; Amir Sandach; Doron Zahger; Hanoch Hod; Haim Hammerman; Shmuel Gottlieb; Solomon Behar; David Hasdai

doi:10.1159/000089548

Aspirin, warfarin and a thienopyridine for acute coronary syndromes

Yuval Konstantino, Zaza Iakobishvili, Avital Porter, Amir Sandach, Doron Zahger, Hanoch Hod, Haim Hammerman, Shmuel Gottlieb, Solomon Behar, David Hasdai

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Background: Although clopidogrel and aspirin (dual therapy, DT) are used for acute coronary syndrome (ACS), sometimes treatment with warfarin (triple therapy, TT) is required. Aim: To determine the incidence, complications, and outcomes of TT. Methods: We analyzed Israeli surveys of ACS from 2000 to 2004. Results: In these surveys, 5,706 (96%) were discharged alive from hospital. Post-ACS TT and DT were 76 patients (1.3%) and 2,661 patients (46.7%), respectively. The TT group was older with more prior cardiac disease. During hospitalization, the TT patients received more intravenous anticoagulant and antithrombotic agents, and had more heart failure, arrhythmias, ischemia, and major bleeding (2.6 vs. 0.6%, p = 0.03). There were no differences in adjusted 30-day and 6-month mortality between the 2 groups. Conclusion: TT is feasible among ACS patients who require concomitant warfarin treatment.

Original language	English
Pages (from-to)	80-85
Number of pages	6
Journal	Cardiology
Volume	105
Issue number	2
DOIs	https://doi.org/10.1159/000089548
State	Published - 1 Feb 2006

Keywords

Acute coronary syndromes
Aspirin
Bleeding
Clopidogrel
Mortality
Warfarin

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000089548

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title = "Aspirin, warfarin and a thienopyridine for acute coronary syndromes",

abstract = "Background: Although clopidogrel and aspirin (dual therapy, DT) are used for acute coronary syndrome (ACS), sometimes treatment with warfarin (triple therapy, TT) is required. Aim: To determine the incidence, complications, and outcomes of TT. Methods: We analyzed Israeli surveys of ACS from 2000 to 2004. Results: In these surveys, 5,706 (96%) were discharged alive from hospital. Post-ACS TT and DT were 76 patients (1.3%) and 2,661 patients (46.7%), respectively. The TT group was older with more prior cardiac disease. During hospitalization, the TT patients received more intravenous anticoagulant and antithrombotic agents, and had more heart failure, arrhythmias, ischemia, and major bleeding (2.6 vs. 0.6%, p = 0.03). There were no differences in adjusted 30-day and 6-month mortality between the 2 groups. Conclusion: TT is feasible among ACS patients who require concomitant warfarin treatment.",

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author = "Yuval Konstantino and Zaza Iakobishvili and Avital Porter and Amir Sandach and Doron Zahger and Hanoch Hod and Haim Hammerman and Shmuel Gottlieb and Solomon Behar and David Hasdai",

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T1 - Aspirin, warfarin and a thienopyridine for acute coronary syndromes

AU - Konstantino, Yuval

AU - Iakobishvili, Zaza

AU - Porter, Avital

AU - Sandach, Amir

AU - Zahger, Doron

AU - Hod, Hanoch

AU - Hammerman, Haim

AU - Gottlieb, Shmuel

AU - Behar, Solomon

AU - Hasdai, David

PY - 2006/2/1

Y1 - 2006/2/1

N2 - Background: Although clopidogrel and aspirin (dual therapy, DT) are used for acute coronary syndrome (ACS), sometimes treatment with warfarin (triple therapy, TT) is required. Aim: To determine the incidence, complications, and outcomes of TT. Methods: We analyzed Israeli surveys of ACS from 2000 to 2004. Results: In these surveys, 5,706 (96%) were discharged alive from hospital. Post-ACS TT and DT were 76 patients (1.3%) and 2,661 patients (46.7%), respectively. The TT group was older with more prior cardiac disease. During hospitalization, the TT patients received more intravenous anticoagulant and antithrombotic agents, and had more heart failure, arrhythmias, ischemia, and major bleeding (2.6 vs. 0.6%, p = 0.03). There were no differences in adjusted 30-day and 6-month mortality between the 2 groups. Conclusion: TT is feasible among ACS patients who require concomitant warfarin treatment.

AB - Background: Although clopidogrel and aspirin (dual therapy, DT) are used for acute coronary syndrome (ACS), sometimes treatment with warfarin (triple therapy, TT) is required. Aim: To determine the incidence, complications, and outcomes of TT. Methods: We analyzed Israeli surveys of ACS from 2000 to 2004. Results: In these surveys, 5,706 (96%) were discharged alive from hospital. Post-ACS TT and DT were 76 patients (1.3%) and 2,661 patients (46.7%), respectively. The TT group was older with more prior cardiac disease. During hospitalization, the TT patients received more intravenous anticoagulant and antithrombotic agents, and had more heart failure, arrhythmias, ischemia, and major bleeding (2.6 vs. 0.6%, p = 0.03). There were no differences in adjusted 30-day and 6-month mortality between the 2 groups. Conclusion: TT is feasible among ACS patients who require concomitant warfarin treatment.

KW - Acute coronary syndromes

KW - Aspirin

KW - Bleeding

KW - Clopidogrel

KW - Mortality

KW - Warfarin

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DO - 10.1159/000089548

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JO - Cardiology

JF - Cardiology

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ER -

Aspirin, warfarin and a thienopyridine for acute coronary syndromes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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