Assessing Dominant-Submissive Behavior in Adult Rats Following Traumatic Brain Injury

Dmitry Frank, Benjamin F. Gruenbaum, Michael Semyonov, Yair Binyamin, Olena Severynovska, Ron Gal, Amit Frenkel, Boris Knazer, Matthew Boyko, Alexander Zlotnik

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Competition over resources such as food, territory, and mates significantly influences relationships within animal species and is mediated through social hierarchies that are often based on dominant-submissive relationships. The dominant-submissive relationship is a normal behavioral pattern among the individuals of a species. Traumatic brain injury is a frequent cause of social interaction impairment and the reorganization of dominant-submissive relationships in animal pairs. This protocol describes submissive behavior in adult male Sprague-Dawley rats after the induction of traumatic brain injury using a fluid-percussion model compared to naive rats through a series of dominant-submissive tests performed between 29 days and 33 days after induction. The dominant-submissive behavior test shows how brain injury can induce submissive behavior in animals competing for food. After traumatic brain injury, the rodents were more submissive, as indicated by them spending less time at the feeder and being less likely to arrive first at the trough compared to the control animals. According to this protocol, submissive behavior develops after traumatic brain injury in adult male rats.

Original languageEnglish
Article numbere64548
JournalJournal of Visualized Experiments
Volume2022
Issue number190
DOIs
StatePublished - 16 Dec 2022

ASJC Scopus subject areas

  • General Neuroscience
  • General Chemical Engineering
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology

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