Assessment of intraocular pressure sensing using an implanted reflective flexible membrane

Andrey Nazarov, Boris Knyazer, Tova Lifshitz, Mark Schvartzman, Ibrahim Abdulhalim

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Glaucoma is a neurodegenerative condition that is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is the main cause for the development of the disease. The symptoms of this form, such as deterioration of vision and scotomas (loss of visual fields), appear in the latter stages of the disease. Therefore, an IOP monitoring device is needed for better, simpler, and faster diagnosis, and to enable a fast treatment response. We present a theoretical assessment as well as preliminary experimental results of a simple approach for easy, optical, IOP self-monitoring. It is based on a polydimethylsiloxane membrane coated with a reflective layer and a Hartmann-Shack wavefront sensor. Nearly linear correlation is found between membrane deformation and Zernike coefficients representing defocus primary spherical aberration, with high sensitivity and negligible dependence on the measurement distance. The proposed device is expected to provide an accurate IOP measurement resolution of less than ±0.2 mm Hg with a pressure dependence on working distances <0.7 mm Hg/cm for a thick membrane; the corresponding values for a thin membrane are ±0.45 mm Hg and <0.6 mm Hg/cm, respectively, at typical IOP values - up to 40 mm Hg.

Original languageEnglish
Article number047001
JournalJournal of Biomedical Optics
Issue number4
StatePublished - 1 Apr 2017


  • flexible membrane
  • intraocular pressure
  • intraocular pressure self-monitoring
  • polydimethylsiloxane
  • wavefront sensor

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering


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